AOAC SPIFAN Stakeholder Panel Meeting Book (March 12, 2020)
General Nutrient Introduction and Background
Calciferol is Inactive Calciferol is Converted to 25-hydroxycalciferol (Calcidiol) in Liver Main Circulating Form Calcidiol is Metabolized to 1,25-dihydroxycalciferol (Calcitriol) by the Kidney Main Biologically Active Form
Helps Regulate Calcium and Phosphorus Blood Levels Enables Normal Bone Mineralization Prevents Rickets in Children Prevents Osteomalacia/Osteoporisis in Adults Modulates Neuromuscular and Immune Function Plays a Role in Reducing Inflammation
Plays a Role in Regulating Cell Proliferation, Differentiation and Apoptosis Vitamin D fortification in infant formula is mandated by all Regulatory Bodies
Regulatory Overview
Historical Landscape – at Time of SMPR Publication
Standard
Regulatory Limits
Regulatory Limits †
Codex, Stan 72-1981
1 – 2.5 g/100kcal
0.65 – 1.63 g/100mL
EU 2006/141/EC
1 – 2.5 g/100kcal
0.65 – 1.63 g/100mL
1980 IFA
1 – 2.5 g/100kcal
0.65 – 1.63 g/100mL
FSANZ, Stan 2.9.1
1.05–2.63 g/100kcal
0.65 – 1.71 g/100mL
† Conversion factor used: 65kcal/100mL. Codex range is 60-70 kcal/100mL per Codex Stan 72-1981 § 3.1.2.
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