AOAC SPIFAN Stakeholder Panel Meeting Book (March 12, 2020)

AOAC 2015.06

Principle of the method- ICP MS detection with microwave assisted digestion 1. Minerals are extracted by digesting the sample with nitric acid and hydrogen peroxide in microwave digester 2. Ge (for 11 elements) and Te (just for Se) are used as internal standards 3. Analysis is performed by inductively coupled plasma mass spectrometry (ICP-MS) 4. Polyatomic interferences are reduced by analyzing in He mode, and for Se, the H 2 mode is used for better sensitivity 5. Quantitation done by comparing the analyte/IS response ratios in the unknown samples to a standard curve constructed from response ratios of calibration standards 6. Two of the Indian matrices (Boost & Horlicks), were subjected to double digestion procedure, for sample preparation to get them completely digested and to get the better recoveries.

Key Milestones - SLV

Activity

Timeline Jan 2019 Mar 2019 Mar 2019 Apr 2019 Dec 2019

Abbott-AOAC (India) Agreement AOAC (India) – TPL Agreement

Mid Year ERP review

SLV Protocol – AN (Joe Thompson) Method set up & validation data

Represent to MRG of FSSAI Manuscript Submission

March 2020

May 2020