AOAC SPIFAN Stakeholder Panel Meeting Book (March 12, 2020)
The validation was performed with LOQ, precision and accuracy determination. The below- mentioned AOAC SMPR criteria were evaluated on Indian Matrices by using the existing AOAC method for its scope extension. SLV - Parameters
SMPR Requirements
Linearity Three-day mean recovery at various levels of high standard (target is <5% calibration bias at 1% of high standard level, or about ½ of the low standard concentration)
Elements Na Mg P
K Ca Mn Fe Cu Zn Cr* Se* Mo*
OVERALL AVG, 0.25% 106.5
102.3 97.3 105.3 101.5 100.5 104.5
109.3
93.5
116.0
97.5 101.4
OVERALL AVG, 1% 107.5
102.4 97.7 104.1 99.1 100.2 103.0
107.8
99.6 103.0 95.4 99.8
OVERALL AVG, 20%
105.9 104.6 99.7 102.8 102.0 98.9 103.2
107.3
101.5 101.2 96.9 99.0
OVERALL AVG, 60%
104.4 103.0 102.5 102.9 101.1 100.8 101.1 101.9 102.4 99.3 98.2 98.4
Conclusion: linearity not quite as expected for Na and Cu – may affect accuracy
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