Research Masterclass in Radiotherapy Physics 2017

Building evidence for RT

4D

R&D – engineering phase, phantom studies, dosimetry in anthropomorphic phantoms

Pre-clinical

INCREASING EVIDENCE

Clinical implementation, QA, process and dosimetry measures, define use of technology

Phase 0

Systematic application in an expanded cohort of consecutive pts, toxicity and efficacy endpoints Bio-effect modeling to estimate clinical relevance of quality improvement WITH 95% CI

Phase I/II

Phase IIIR or Phase IIINR

Controlled clinical trial – randomized if possible or opt-in on institutional basis, toxicity & efficacy

Post-marketing recording of outcomes, generalizability of results when rolled out in the community

Phase IV

Courtesy of S. Bentzen