Research Masterclass in Radiotherapy Physics 2017

Conclusions

22

Mice hind leg arteries tolerate doses of up to 2,000 Gy delivered by spatially fractioned MPBs in a single session without occlusion development within 1 year, in contrast to the deleterious consequences of comparable doses delivered by seamless X-rays.

The permanent sequelae of microplanar irradiation appear to be confined.

Boudewijn van der Sanden, Elke Bräuer-Krisch et al. “Tolerance of small arteries for high dose X-ray microplanar beams depends on smooth muscle cells of the normal media ” International Journal of Radiation Oncology, Biology, Physics. Ms. No. ROB-D-09-01479R2

Courtesy of EBK