Research Masterclass in Radiotherapy Physics 2017

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Normal Tissue Sparing: Piglet cerebellum

Normal tissue sparing

300 Gy

Piglet cerebellum 15 months post ir.

- Cell death and damages observed only along the microbeam paths - No damage in between microbeams - No macroscopic tissular necrosis observed as in conventional therapy

Hyp: no necrosis ↔ no damage on normal brain vasculature

Laissue et al. Proceedings of SPIE . 4508. 2003 Dilmanian et al. Neuro-oncol . 2002. Vol 4. p. 26-38 Slatkin DN et al. Med Phys . 1992. Vol 19. p. 1395-400

Courtesy of EBK