Research Masterclass in Radiotherapy Physics 2017

MB irradiation of Zebrafish

Beam Width 100µm, 6 hpi (hours post irradiation) Morphology

Interrupted vessels in beampath

Intact vasculature

Conclusion: Zebrafish is a good model to study the sensitivity to MBs, clearly depending on the developing state of the vasculature with similarities between normal tissue vasculature and tumor vasculature.

Daniel Broennimann, Audrey Bouchet, Christoph Schneider, Marine Potez , Raphaël Serduc, Elke Bräuer-Krisch, Werner Graber, Stephan von Gunten, Jean Albert Laissue and Valentin Djonov Synchrotron microbeam irradiation induces neutrophil infiltration, thrombocyte attachment and selective vascular damage in vivo Scientific reports, 2016

Courtesy of EBK