Research Masterclass in Radiotherapy Physics 2017

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Microbeams and Radiosensitizer

MRI results of rat brain glioma before and 5, 20 and 45 minutes after injection of gadolinium NPs.

9LGS bearing rats, without treatment (black dashed curve, only treated by MRT (blue curve) and treated by MRT 5 minutes (red curve) and 20 minutes (green curve) after NPs intravenous injection. The MRT irradiation was done in cross fired mode: 50 micron FWHM, spacing of 211 microns. The skin entrance dose was set up at 400 Gy for the peak.

Le Duc G, Miladi I, Alric C, Mowat P, Bräuer-Krisch E, Bouchet A, Khalil E, Billotey C, Janier M, Lux F, Epicier T, Perriat P, Roux S, Tillement O. Toward an image-guided microbeam radiation therapy using gadolinium-based nanoparticles. ACS Nano. 2011 Dec 27;5(12):9566-74. Epub 2011 Nov 9. "The High Radiosensitizing Efficiency of a Trace of Gadolinium-Based Nanoparticles in Tumors" by Dufort S, Le Duc G, Salomé M, Bentivegna M, Sancey L, Bräuer-Krisch E., Requardt H, Lux F, Coll JL, Perriat P, Roux O, Tillement O. Scientific Reports, 2016

Courtesy of EBK