Research Masterclass in Radiotherapy Physics 2017

Modelling tumour response: a long successful story  Fit of Clinical Data on local control/survival  Models of fractionation (LQ)  Population-based TCP models  Incorporating repopulation, hypoxia, functional imaging information…  Incorporation of dose distribution heterogeneity, Dose painting and response’s models for resistant sub- volumes…  Models of tumour progression and regression  Models of secondary cancer induction

For a given fraction size

TCP

100

80

TCP & NTCP (%) 0 20 40 60

Therapeutic Ratio

NTCP

D

20

40

60

80

100

pr

Dose (Gy)