Research Masterclass in Radiotherapy Physics 2017

Overcoming organ-based approach of dose-volume modelling

 Organ-based…an intuitive and natural way to describe radiotherapy-induced effects  Organs as «independent and homogeneous entities» is a robust and practically usable approximation for most end-points  Supported the translation from «qualitative» to «quantitative» RT ….knowledge condensed into organ constraints/EUDs/NTCPs  Successful in reducing toxicities by guiding RT to «safely» deliver treatments respecting organ-based constraints  Conserving a «flavour» of Radiobiology (....serial and parallel-like organs…)  «Easy» incorporation in multi-variable phenomenological models