Particle Therapy 2017

Biological uncertainties

R. Mohan, D. Grosshans, Proton therapy – Present and future, Adv. Drug Deliv. Rev. (2016)

Over the last years 3 publications of unexpected brain image alterations or brain necrosis at presumably safe

A two-beam IMPT plan for brain tumor op6mized based on criteria defined in terms of constant RBE of 1.1 (squares) and in terms of variable RBE computed using a model published byWilkens, et al. (triangles). AKer op6miza6on, both dose distribu6ons were converted to variable RBE- weighted dose for comparison. Gy(RBE) levels in children undergoing proton therapy for CNS tumors