Particle Therapy 2017

The Domain of Carbon Ion Therapy at NIRS • with large proportion of hypoxic cells • do not well re-oxygenate • with broad-shouldered dose survival curves by low LET radiation ( small α ҈ β ratio ) • slowly proliferating Tumors ; biological view points for high LET beam • empirically radio-resistant, such as sarcomas, melanoma, RCC, thyroid ca, and re-irradiation • located close to radiosensitive organs ; para-spinal • Not candidate to other therapies such as second surgery, limb amputation, concurrent chemo-radiation etc. Tumors ; clinical context (practical) mainly conformality