Particle Therapy 2017

Clonogenic survival

Late cell death Apoptosis, Necrosis

Vast majority of proliferating normal cells

Most tumor cells

Mitotic

catastrophe

Cell cycles

Multiple cell cycles

Apoptosis, Necrosis

Early cell death

Mitosis

Normal cells: lymphocytes, spermatogonia, intestinal cells, embryonal cells Tumors of haematopoetic origin

DNA

damage

response

Adopted from Wouters 2009 When and why cells die after irradiation ? senescence = cells cease to divide