Particle Therapy 2017

modified from Coleman CN, Radiotherapy and Oncology 46: (1998) DNA repair cell death

stress

growth

factors

response

vasculogenesis

Summary

gene

activation

DNA

damage

.

O

2

O

2

signal

Neighbouring tumor or stroma cells

transduction

lipid

peroxidation

receptor

cell cycle effects

external

effectors

O2, nutrients etc.

endocrine factors

inflammatory molecules

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