Particle Therapy 2017

> 20 keV/µm

high-LET

Krämer & Kraft 1994

(LET)

average energy deposition (keV) per traversed distance (1 µm) low-LET < 20 keV/µm

Linear Energy Transfer

Density of ionization in particle tracks is described Definition:

m m

10

Carbon Ions

„Clustered DNA damage“

Cell nucleus

X-rays

Physics meets biology

Local Microscopic Dose Distribution

„Randomized DNA damage“