Biophysical Society 62nd Annual Meeting | Program Guide

Voltage-gated Ca Channels (Boards B363–B378)

3142-Pos Board B350 THERMAL MELT CIRCULAR DICHROISM SPECTROSCOPY OF MEMBRANE PROTEINS AS A TOOL FOR CRYO-EM PREPARATIONS. Altin Sula , SamM. Ireland, Jennifer Booker, B. A. Wallace 3143-Pos Board B351 DEVELOPMENT OF HIGH THROUGHPUT ELECTROPHYSIOLOGY ASSAYS OF RECOMBINANT NAV1.9 CHANNELS. Matthew D. Fuller , Chris Mathes, Zhixin Lin, Mark L. Chapman, Nina Brinkwirth, Claudia Haarmann, Mi- chael George, Niels Fertig, Andrea Brüggemann 3144-Pos Board B352 THE ROLE NA V 1.9 IN SOMATOSENSORY SIGNALING.  Juan Salvatierra , Frank Bosmans, Marcelo Diaz-Bustamante, James Meixiong, Xinzhong Dong 3145-Pos Board B353 PYRROLINE DERIVATIVES OF MEXILETINE-LIKE COMPOUNDS HAVE DUAL ACTIVITY AS USE-DEPENDENT SODIUM CHANNEL BLOCKERS AND ANTI- OXIDANT. Michela De Bellis, Francesca Sanarica, Alessia Carocci, Giovanni Lentini, Sabata Pierno, Diana Conte Camerino, Annamaria De Luca 3146-Pos Board B354 POPULATION-BASED MATHEMATICAL MODELING TO DEDUCE DISEASE- CAUSING CARDIAC NA + CHANNEL GATING DEFECTS. Chiara Campana , Ivan Gando, Reina Bianca Tan, Frank Cecchin, William A. Coetzee, Eric A. Sobie 3147-Pos Board B355 I NA LOSS-OF-FUNCTION BY COMPOUND VARIANTS IN SCN5A FROM A LARGE FOUNDER POPULATION WITH EXCESS SUDDEN CARDIAC DEATH. Cristina Altrocchi , Roel R.L. Spätjens, Henry Sutanto, Rachel M.A. ter Bekke, Sandrine Seyen, Jordi Heijman, Cristina Moreno, Paul G.A. Volders 3148-Pos Board B356 ASSESSING THE STRUCTURAL BASIS OF Μ-CONOTOXIN KIIIA INHIBITION OF THE VOLTAGE-GATED SODIUM CHANNEL NAV1.7.  Ian H. Kimball , Phuong T. Nguyen, Jon T. Sack, Vladimir Yarov-Yarovoy 3149-Pos Board B357 INTERMEDIATE STATES AND STRUCTURAL ENSEMBLES OF CALMODULIN BOUND TO THE NA V 1.2 IQ MOTIF. Ryan Mahling , Adina M. Kilpatrick, Holly M. Isbell, Madeline A. Shea 3150-Pos Board B358 CALMODULIN REGULATION OF NAV1.8 CHANNEL. Liang Hong , Meihong Zhang, Erin Lambers, Arvind Sridhar, ambili Menon, Dawood Darbar 3151-Pos Board B359 CALMODULIN RECOGNITION OF VOLTAGE-GATED SODIUM CHANNELS NA V 1.1, NA V 1.4 AND NA V 1.7. Holly M. Isbell, Adina M. Kilpatrick, Zesen Lin, Ryan Mahling, Madeline A. Shea 3152-Pos Board B360 HYPOKALEMIC PERIODIC PARALYSIS CASES WITH SUBSTITUTIONS FROM ARGININE TO LYSINE IN THE VOLTAGE SENSOR. Maki Nakaza , Tomoya Kubota, Savine Vicart, Daisuke Watanabe, Norito Kokubun, Mitsuru Fu- ruta, Damien Sternberg, Yosuke Kokunai, Tatsuya Abe, Bertrand Fontaine, Masanori P. Takahashi 3153-Pos Board B361 MOLECULAR BASIS OF MEXILETINE RESPONSE VARIABILITY IN SODIUM CHANNELS WITH LONG QT MUTATIONS. Wandi Zhu , Taylor L. Voelker, Jonathan D. Moreno, Andrea Mazzanti, Silvia G. Priori, Jonathan R. Silva 3154-Pos Board B362 EFFECTS OF CANNABIDIOL ON HUMAN NAV CHANNELS. Mohammad- Reza Ghovanloo , Noah Gregory Shuart, Janette Mezeyova, Peter C. Ruben, Samuel J. Goodchild

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3155-Pos Board B363 GATING DEFECTS OF A CACNA1D MISSENSE MUTATION LINKED TO A DEVELOPMENTAL DISORDER OF UNKNOWN CAUSE. Nadja Hofer , Joerg

Striessnig 3156-Pos

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Board B364 DHEA-INDUCED INHIBITION OF I CAL IN ARTERIAL SMOOTH MUSCLE CELLS. INVOLVEMENT OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE AND GPCR SIGNALING. Rikuo Ochi , Sukrutha Chettimada, Sachin A. Gupte 3157-Pos Board B365 PROBING THE VOLTAGE-SENSING MECHANISM OF CA V 1.1 CALCIUM CHANNELS AT SINGLE CHANNEL RESOLUTION. Pierre Costé de Bagneaux , Bruno Benedetti, Petronel Tuluc, Marta Campiglio, Bernhard Flucher 3158-Pos Board B366 RGK PROTEINS PREFERENTIALLY INHIBIT FAST-INACTIVATING VOLTAGE- GATED CALCIUM CHANNELS: IMPLICATIONS FOR HUMAN DISEASE. Salma Allam, Rose Levenson-Palmer, Zuleen Chia Chang, Kaur Sukhjinder, Scott Dobbins, Jian Yang, Zafir Buraei 3159-Pos Board B367 A COMPLEX OF RIM2ALPHA AND RIM-BINDING PROTEIN 2 STABILIZES SLOW VOLTAGE-DEPENDENT INACTIVATION OF COCHLEAR INNER HAIR CELL CAV1.3 L-TYPE CA 2+ CHANNELS. Nadine J. Ortner , Alexandra Ping- gera, Anita Siller, Nadja Hofer, Niels Brandt, Andrea Raffeiner, Isabelle Lang, Eduard Stefan, Gerald J. Obermair, Jutta Engel, Jörg Striessnig 3160-Pos Board B368 FUNCTION OF L-TYPE CALCIUM CHANNEL MICRODOMAIN IN HUMAN MYOCYTES FROM HEARTS WITH ISCHEMIC VERSUS DILATED CARDIO- MYOPATHIES.  Jose L. Sanchez-Alonso , Sophie Schobesberger, Claire E. Poulet, Navneet Bhogal, Rasheda Chowdhury, Julia Gorelik 3161-Pos Board B369 MOLECULAR MECHANISM OF VOLTAGE-GATED CA 2+ CHANNEL REGULA- TION BY MEMBRANE PIP 2 . Cheon-Gyu Park , Byung-Chang Suh 3162-Pos Board B370 STAC PROTEINS ASSOCIATE TO THE IQ DOMAIN OF CA V 1.2 AND INHIBIT CALCIUM-DEPENDENT INACTIVATION. Marta Campiglio , Pierre Costé de Bagneaux, Nadine J. Ortner, Petronel Tuluc, Bernhard E. Flucher 3163-Pos Board B371 VOLTAGE-GATED CALCIUM CHANNEL Α1-SUBUNITS REGULATE CARDIAC FUNCTION OF THE AGING HEART OF D. MELANOGASTER . Alexander Lam , Priyanka Karekar, Girija Hariharan, Michelle Fleyshman, Kajol Shah, Harpreet Singh, Shubha Gururaja Rao 3164-Pos Board B372 A NOVEL FORM OF CA V 1.4 CA 2+ CHANNEL REGULATION REVEALED BY AL- TERNATIVE SPLICING AND A MUTATION CAUSING CONGENITAL STATION- ARY NIGHT BLINDNESS. Brittany Williams , amy Lee 3165-Pos Board B373 GATING PORE CURRENTS IN DIII HYPOPP MUTATIONS OF CA V 1.1. Fenfen Wu, Marbella Quinonez, Steve C. Cannon 3166-Pos Board B374 THE ANTIHYPERTENSIVE CALCIUM CHANNEL BLOCKER NITRENDIPINE DISPLAYS A CYTOTOXIC EFFECT ON NEUROBLASTOMA CELLS, WHICH IS INDEPENDENT OF BINDING TO L-TYPE VOLTAGE-GATED CALCIUM CHAN- NELS. Antonio De Maio , Isabel Rivera, David M. Cauvi, Nelson Arispe

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