PAC_App_CVs

Curriculum Vitae

Nour-Eddine ES-SAFI Date of birth: 04/20/1962 Place of birth: Morocco.

ADDRESS

Team of Organic Chemistry and Physical and Chemical Studies. Mohammed V - University in Rabat Ecole Normale Supérieure B.P 5118 Takaddoum, Rabat, Morocco. Ph. : +212 5 37 75 80 96. Mobile: +212 6 72 64 30 86. Fax.: +212 5 37 75 90 63. E-mail: nouressafi@yahoo.fr

ACADEMIC EDUCATION

1997 :

Ph.D in Organic Chemistry. Mohammed V University in Rabat, Morocco. Thesis entitled “ Phenolic compounds of red vine ( Vitis vinifera L.) cultivated in Morocco: Structure, reactivity and pharmacological properties ”. Master of Science in Organic Chemistry. Ecole Normale Supérieure, Rabat, Morocco. Thesis entitled “ Contribution to the study of essential oils and tanins of Eucalyptus trees cultivated in Morocco ” Certificate for teaching chemistry in training centers frames. Ecole Normale Supérieure Rabat, Morocco. Graduate of the Ecole Normale Supérieure, Option Physique – Chimie, Rabat, Morocco.

1990 :

1986 :

1984 :

Curriculum Vitae - N. ES-SAFI - August 9, 2017.

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EMPLOYMENT July 2014- Present: Deputy Director of the Ecole Normale Supérieure. Mohammed V University in Rabat – Morocco. Jan 2001-Present: Professor at Mohammed V University in Rabat. Ecole Normale Supérieure, Rabat – Morocco (Chemisty department). Jan 1997- ‏ 2001: Associate Professor at the same department. 1986-1997 : Assistant Professor at the same department. 1984-1986 : Assistant at the same department.

PROFESSIONAL EXPERIENCE

Research Competence:

Expertise in synthesis of natural bioactive molecules.

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 Dexterous in isolation and characterization of natural bioactive molecules.

Endured in minor natural products purification.

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Familiar with HPLC and related chromatographic techniques.

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 Adept in analyzing spectral data like 1 H, 13 C, 2D NMR (COSY, NOESY, HMBC and HMQC), IR and MS (ESI-MS, Tandem MS-MS, Maldi-Tof MS).

Design and synthesis of biologically active compounds.

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 Development of synthetic methodologies for natural/modified compounds synthesis.  Isolation and characterization of naturally occurring bio-active compounds, hemisynthesis of isolated natural products for the confirmation of their chemical structures, transformations of natural products into their novel derivatives.  Isolation of novel compounds (polyphenols, iridoids, phenylethanoids) from Moroccan plants.  Development of regio- and stereoselective methodologies for modified polyphenols synthesis.  Development of thioacidolysis method for structural elucidation of bridged flavanols.

Capable of both collaborative and independent research.

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Possession of good communication and management skills.

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Research Conducted or Supervised  Natural Products:

Essential oils, polyphenols, iridoids

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 Eucalyptus trees: Extraction, quantitative and qualitative analysis of essential oils (leaves) and condensed tannins (bark).  Vine leaves polyphenols (proanthocyanidins, flavonols, anthocyanidins): Extraction, quantitative analysis, isolation and identification by spectroscopic tools (mass and 1D and 2D NMR spectroscopy).  Phytochemical investigations of various Moroccan medicinal plants used in traditional pharmacopeae.

 Analytical methods:

 Chromatography: HPLC/DAD, HPLC/ESI-MS. Application to the study of the condensation of flavanols and anthocyanins in model solution systems.  Spectroscopy: ESI/MS, MS/MS, ICD MS, 1D ( 1 H, 13 C) and 2D (COSY, HSQC, HMBC, NOESY, ROESY) NMR techniques. Application to the structural elucidation of natural and synthesized compounds.

 Composition of foods:

 Grape proanthocyanidins: Extraction from different parts (seeds, stems and skins), quantitative and qualitative analysis by HPLC and cleavage methods (thiolacidoysis).

Grape anthocyanins: Extraction, quantitative and qualitative analysis.

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Food polyphenols and their role in human health

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Polyphenols and their role in food technology

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 Flavor and aroma:

 Essential oils: extraction, analysis by GC/MS techniques, antibacterial and antifungal properties.

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 Chemical changes during processing:

 Chemical transformations which contribute to the organoleptic properties alterations (de-astringency, browning, darkening, etc …) of foods during processing, maturation, storage and aging.  Evolution of phenolic compounds during processing, maturation, storage and aging of foods in model solution systems.  Evolution of phenolic compounds in model solution systems. Detection, isolation and identification of the new formed compounds and confirmation of their presence in in foods.  Role of the new formed compounds in food organoleptic properties and huaman health.

 Pharmacological activity:

 Antibacterial and antifungal activity of natural and synthesized compounds.

 Mollusciscidal activity of proanthocyanidols and flavonols isolated from grapes and vine leaves.  Antioxydant and free radical scavenging properties of natural and synthesized compounds.

Strucure-activity relationships.

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Teaching Experience

 Organic Chemistry: Stereochemistry, reactions, mechanisms and structures.

Natural Products.

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Spectral Analysis: IR, MS, NMR.

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Chromatography: PC, GPC, HPLC.

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Polyphenols chemistry.

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Scientific stays in foreign laboratories:

 Unité de Phytopharmacie et Médiateurs Chimiques. Team: Chemistry of Natural Products. National Institute for Agricultural Research, Versailles, France.  UMR Sciences for Enology. Polyphenols team. National Institute for Agricultural Research, Montpellier, France.

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 Laboratory of Polyphenols. National Institute for Agricultural Research, Narbonne, France.  Materia Medica and Pharmacognosy Laboratory, School of Pharmacy, Montpellier, France.. LANGUAGES  English, French and Arabic (Native Language): Writing, Speaking and Reading.

MICROCOMPUTER USE

Operating systems : WINDOWS

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MS OFFICE

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Others: Chemdraw, Chemsketch, … etc.

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OTHERS

 Deputy Director of Ecole Normale Supérieure, Rabat, Morocco. Since July 2014.  Head of the Chemistry department at Ecole Normale Supérieure, Rabat, Morocco. 2011-2014.  Professor at Ecole Normale Supérieure, Mohammed V University of Rabat. Since 2001.  Responsible of the research team "Organic Chemistry and Physical and Chemical Studies".  Responsible of the Research Master "Valorization of the natural resources plant".  Responsible of the professional bachelor's degree "university course teaching in physics and chemistry".  Expert Review Panel for the AOAC Stakeholder Panel on Strategic Food Analytical Methods (Flavanols, St. John's Wort, Chondroitin, Kratom, Ashwagandha, Folin C, …)  Member of various scientific associations.  Post-doc at the French National Agricultural Research Institute. Montpellier & Versailles INRA centers.  Supervisor of PhD students.  Author of many scientific papers  Editor in Chief of Green and Sustainable Chemistry journal  Regional Editor of the American Journal of Food Technology.

Curriculum Vitae - N. ES-SAFI - August 9, 2017.

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 Guess Editor of Current Bioactive Compounds journal special issue on "Current Hyphenated Methods in Polyphenol Analysis".  Editorial Board Member of various scientific journals

Journal of Food Composition and Analysis

o

Current Bioactive Compounds

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Organic Chemistry Insight

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The Open Agriculture Journal

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The Open Natural Products Journal

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The Open Organic Chemistry Journal

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o International Journal of Medicinal and Aromatic Plants

Reviewer for many scientific journals o

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American Journal of Food Technology

Arabian Journal of Chemistry

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Asian Journal of Agricultural Research

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Biotechnology

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British Journal of Pharmacology

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Current Bioactive Compounds

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Food Chemistry

o

International Journal of Agricultural Research

o

International Journal of Dairy Science

o

International Journal of Food Sciences and Technology

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International Journal of Pharmacology

o

Journal Marocain de Chimie Hétérocyclique

o

Journal of Agricultural and Food Chemistry

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Journal of Chromatography A

o

Journal of Food Biochemistry

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Journal of Food Composition and Analysis

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Journal of Molecular Structure

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Journal of Mass Spectrometry

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Journal of Natural Products

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Journal of Pharmaceutical and Biomedical Analysis

o

Journal of Physical Chemistry

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Journal of Separation Science

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Journal of the Science of Food and Agriculture

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Journal of Zhejiang University-SCIENCE B

o

Curriculum Vitae - N. ES-SAFI - August 9, 2017.

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LWT-Food Science and Technology

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Molecules

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Natural Products Research

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Pakistan Journal of Biological Sciences

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Phytochemical analysis

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Phytochemistry

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Rapid Communications in Mass Spectrometry

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Recent Patents on Food, Nutrition & Agriculture

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Tetrahedron Letters

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The Open Agriculture Journal

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The Open Natural Products Journal

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The Open Organic Chemistry Journal

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The Open Spectroscopy Journal

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Curriculum Vitae - N. ES-SAFI - August 9, 2017.

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FRM-580.01

Replaces: FRM-580.00 Effective Date: 04/14/2011 Approved by: On File APT QA Review: On File AJW

Abbreviated Resume Curriculum Vitae (CV)

Name: Ramin Jahromi

Position: Technical Manager

Branch Location: Nutrition Analysis Center-Des Moines

Department: Authenticity

Summary: 1989 to September 2011- Chief Analytical Chemist, Eurofins-Hanover (ESS) September 2011 to Dec 2014- Technical Manager-Juice Authenticity & Elemental, Eurofins- Nutrition Analysis Center September 2011 to present- Technical Manager-Juice Authenticity, Eurofins-Nutrition Analysis Center 2016 to present-Final reports review and submission TCJJP (Technical Committee for Juice and Juice Products) Chair Elect-2012-2014 Chair-2014-2016 Executive Board-2016-2018 American Spice Trade Association-Methods Committee board member 2017 to present Education: B.S. Chemistry, Towson University with Honors Degree Accredited by American Chemical Society, 1989 Research: Use of Perfluorinated Compounds in NMR Imaging Masters certificate in Systems Design, Cornell University College of Engineering 1993 Gas Chromatography by CFDV (three days) 1999 HPLC Training by Chromatograhy Institue of America (one day)

11/6/2017

Q:\Forms\Default\FRM-580.01 Abbreviated Resume

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FRM-580.01

Replaces: FRM-580.00 Effective Date: 04/14/2011 Approved by: On File APT QA Review: On File AJW

Abbreviated Resume Curriculum Vitae (CV)

2004 Mas Spectroscopy Training by Shimadzu (5 days) 2011 Juice Authenticity at Eurofins, Nantes (3 days) 2012 Certificate in Project Leadership, Cornell University

Experience: Over 28 years of experience in analytical chemistry and laboratory equipment including routine such as balances/pH Meter and specialized such as Gas Chromatographs, HPLC, AA/FE, GC/MS. Extensive knowledge of Methods published by AOAC International, USDA-FSIS, USP/NF, FCC, Water & Waste Water Analytical Manual, ASTA and IFU Methods . From 1989 to present: has been performing varoius tests on Food, Juice, Spice and Environmental samples.

11/6/2017

Q:\Forms\Default\FRM-580.01 Abbreviated Resume

Curriculum Vitae Holly E. Johnson, Ph.D. Alkemist Labs, 1260 Logan Ave, Costa Mesa, CA 92626 USA holly@alkemist.com 808.631.8823

Academic Degrees

2007 Ph.D. in Pharmacognosy

Specialization: Natural Products Chemistry & Medical Ethnobotany Department of Medicinal Chemistry & Pharmacognosy Program for Collaborative Research in the Pharmaceutical Sciences College of Pharmacy, University of Illinois – Chicago, IL

1997 B.S. in Environmental Biology, B.S. in Botany Department of Biological Sciences Humboldt State University, Arcata, CA

Professional Experience

2014 - present 2013 – present 2013 – 2014 2010 – 2013 2009 – present 2009 – 2011

Laboratory Director , Alkemist Labs, Costa Mesa, CA

Scientific & Regulatory Consultant , Natural Products Consulting, CA Senior Field Applications Chemist , Waters Corp., Milford, MA

Adjunct Professor , University of Hawaii, Lihue, HI

Research Associate , National Tropical Botanic Garden, Kalaheo, HI Researcher , University of Hawaii – Manoa, College of Tropical Agriculture & Human Resources, Kapaa, HI Visiting Assistant Professor , Weber State University, Department of Botany, Ogden, UT Postdoctoral Research Fellow , Institute for Ethnomedicine, Jackson, WY Senior Analytical Technician , California State University -Fullerton Department of Biological Sciences, Fullerton, CA Analytical Chemistry Consultant , Institute for Ethnobotany, Acacia Lab, National Tropical Botanic Garden, Kalaheo, HI Pre-Doctoral Fellow , National Institutes of Health Center for Botanical Dietary Supplements Research, Chicago, IL Pharmacology/Toxicology Production Associate , NAPRALERT™ Database, University of Illinois – Chicago, IL Research & Teaching Assistant , National Cooperative Drug Discovery Group, Program for Collaborative Research in the Pharmaceutical Sciences, Chicago, IL

2007 – 2011

2007 – 2009

2005 – 2007

2003 – 2005

2000 – 2003

1998 – 2002

1997 – 2000

Honors

2001 – 2003

National Research Service Awards (NIH #1F31AT000064-01 & NIH #5F31AT000064-02) National Institutes for Health - Center for Botanical Dietary Supplements Research in Women's Health

2000

Charles Wesley Petranek Memorial Scholar University of Illinois – Chicago

1997

Meredith Botany Scholar Humboldt State University

Research Interests

Botanical dietary supplements; natural products chemistry; analytical methods development & validation for natural products; ethnopharmacology; authentication & Quality testing of botanicals in commerce; dietary supplements regulatory compliance with 21 CFR part 111.

Botanical Field Experience

Dominican Republic, Puerto Rico, Mexico, Venezuela, El Salvador, Costa Rica, Peru, Guam, American Samoa, Western Samoa, Tonga, Fiji, Sweden, Canada, the Hawaiian Islands, continental U.S.A. including California, Wyoming, N. Carolina & Florida.

Membership in Professional Societies & Technical or Advisory Boards

American Association for the Advancement of Science American Botanical Council (Advisory Board Member) American Chemical Society (Cannabis Chemistry SD Member) American Herbal Products Association (Cannabis Committee Member) American Herbal Pharmacoepia (Advisory Board Member) American Society of Pharmacognosy (Membership Committee Chair) AOAC International (Editorial Board Member of Journal AOAC Intl.) Botanical Society of America International Society for Ethnopharmacology Society for Economic Botany Phytochemical Society of North America

Christian G. Krueger Curriculum Vitae

Work Address

Work Address

Complete Phytochemical Solutions, LLC

University of Wisconsin-Madison

317 South Street Cambridge, WI 53523 Office:608-890-1396 Cell: 608-212-1816 ckrueger@phyto-sol.com

1675 Observatory Drive Madison, WI 53706 Office:608-423-1327 Cell: 608-212-1816 ckrueger@wisc.edu

PROFESSIONAL RECORD:

Director of Operations & Research Program Manager II (Principal Investigator Status), Reed Research Group • Cardiovascular, Mucosal Immunology, and Phytochemistry Research Cores, Department of Animal Sciences, University of Wisconsin – Madison, Madison, WI Managing Director, Synesis Separations, LLC., Wisconsin Rapids, WI Managing Director, Synesis, LLC., Wisconsin Rapids, WI Co-Founder and Chief Executive Officer, Complete Phytochemical Solutions, LLC., Cambridge, WI Research Program Manager I (Principal Investigator Status), Reed Research Group • Cardiovascular, Mucosal Immunology, and Phytochemistry Research Cores, Department of Animal Sciences, University of Wisconsin – Madison, Madison, WI Senior Research Specialist , Mass Spectrometric Methods of Food Analysis ( Director: Dr. Jess D. Reed ), Department of Animal Sciences, University of Wisconsin – Madison, Madison, WI Research Specialist , Diet Composition Health and Disease ( Director: Dr. Jess D. Reed ), Department of Animal Sciences, University of Wisconsin – Madison, Madison, WI Research Specialist , University of Zimbabwe Partnership - Ecological Biochemistry of Feeds and Forages ( Director: Dr. Jess D. Reed ), International Agricultural Programs, University of Wisconsin – Madison, Madison, WI Phytochemist , Nutrasorb, LLC. North Brunswick, NJ

2016 – Present

2016 – Present 2014 – Present

2010 – Present

2012 – 2013

2006 – 2016

2002 – 2006

1999 – 2002

1995 – 1999

EDUCATION:

Bachelor of Science , College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison Wisconsin. May 1995. Major: Bacteriology. Professional Development Education (Credit course-work, University of Wisconsin-Madison) 2003 Topics in experimental cellular biology/immunology (875) 2002 Introduction to mass spectrometry: Mass spectrometry for biotechnology (638)

2000 1999

Mega-Surgery laboratory training course through RARC. The plant cell wall and fiber in animal and human nutrition (875) Statistical methods for bioscience II (572) Seminar in animal nutrition (931)

1998

Comparative animal nutrition (311) Seminar in animal nutrition (931) Statistical methods for bioscience I (571)

1997

PROFESSIONAL SKILLS:

Administration and Management : Administrate; Industry, Federal and State sponsored research grants, fee-for-service contracts, consulting services, and a University of Wisconsin-Madison Foundation account. Manage large breeding colonies of Wisconsin Miniature Swine TM , Wisconsin Miniature Swine – Familial Hypercholesterolemia TM and Rapacz Familial Hypercholesterolemic Swine for agricultural and translational bio-medical research. Establish and maintain collaborative relationships. Hire full time, limited time and student hourly employees. Supervise and train; undergraduate, graduate, international scholars and professional personnel. Oversight over multiple Principal Investigator research program’s annual operational budget at the University of Wisconsin-Madison. Manuscript preparation, grantsmanship, continuation applications, animal care and bio-safety protocols. Principal Investigator: Research emphasis in the fields of phytochemistry, mucosal immunology and cardiovascular disease. Responsible for generating operating funds through competitive intra- and extramural grants, sponsored research agreements and business service agreements with industry. Medical Imaging Instrumentation : Phased and linear array echocardiography ultrasound (GE, Siemens, Ultrasonix systems), C-arm fluoroscopy/x-ray, Optical Coherence Tomography, and Intravascular Ultrasound. Chemistry Instrumentation: Matrix assisted laser desorption/ionization time-of-flight mass spectrometry (Bruker: Reflex II, Biflex II & Ultraflex), electrospray ionization mass spectrometry (Shimadzu LCMS 2010), high performance liquid chromatography (Waters, photo diode array detector / Empower & Millennium 32 software), counter current chromatography (Pharama-Tech). Repair, maintain and trouble-shoot instruments. Surgical (Large Animals) : Contrast enhanced ultrasound (CEUS) quantification of atherosclerosis and vasa vasorum, high intensity focused ultrasound (HIFU) arterial repair, transesophageal ultrasound identification of patent foramen ovale, radio- frequency ablation liver resection, dual energy x-ray (DEXA) analysis of body composition, subcutaneous placement of vascular access ports, Cesarean section, peripheral artery angioplasty to induce vascular lesions, implantation of intracranial pressure transducer. Surgical preparation, record keeping, anesthesia. Technical : Analytic, semi-preparative and preparative liquid chromatography. Folin Ciocaleau, Butanol-HCl, DMAC assays for quantification of polyphenols from foods/forages. Crude fiber (NDF, ADF and lignin) and protein (Kjeldahl) forage analysis. Histological techniques from tissue preparation, cryostat, microtome, histo-chemistry, and microscopy. Quality control, experimental design, record keeping, data analysis and results published.

TEACHING / MENTORING EXPERIENCE:

Teaching Assistant 1999 “The plant cell wall and fiber in animal and human nutrition”, in the Dept. of Dairy Science at the University of Wisconsin-Madison. Mentor Biology 152 Undergraduate Independent Research Project 2009 Mike Shea – ‘Quantification of total polyphenols in pomegranates by the use of a pomegranate standard and method’. 2008 Michelle Wenzel – ‘Ultrasound guided transcutaneous intra-arterial injection to generate atherosclerotic lesions’. 2007 Rajeev Chaudhary – ‘The Effects of Familial Hypercholesterolemia (FH) on FH Cross Swine and Their Relationship with FH Cross Humans’. 2007 Jake Jursada- ‘ The effect of diet composition (fructose and fat) on uric acid levels in urine’. 2006 Allison Donenberg – ‘The effect of cranberry-filled diet on the amount of polyphenols, particularly cranberry flavonoids, in a sow’ urine’. 2006 Laura Nicholl- ‘ The effects of a cranberry powder diet on the levels of polyphenolic compounds in sow urine’.

FUNDED GRANTS IN ROLE AS PRINCIPAL INVESTIGATOR AT UW-MADISON:

2016 Sponsored Research Agreement with Johnsonville; Extraction and Characterization of Antimicrobial Proteins and Peptides from Animal By-products. Funded $248,825 (9/2016-4/2018) 2016 Cranberry Institute Grant: Urinary proteome and fecal microbiome markers of gut barrier dysfunction. Funded $148,665 (5/2016-7/2017) 2014 Sponsored Research Agreement with the Cardiovascular Research Foundation; Refinement and Further Characterization of the Rapacz Familial Hypercholesterolemic (FHS) Swine Model for Cardiovascular Research. Funded $358,778 (6/2014 – 5/17) 2014 NIH RO1; Detection and Characterization of TCFA Using Combined HD-IVUS & IVPA Imaging (Sub-Contract, Stanislav Emelianov, University of Austin, TX). Funded $225,000 (10/2014-9/2018). 2014 Cranberry Institute Grant: Consuption of sweetened, dried cranberries and the gut microbiome, the urinary proteome and the urinary and fecal polyphenolic metablolome. Funded $67,494 (6/2014-5/2015) 2014 Sponsored Research Agreement with Biodaptive; Tannin-Chitosan Films and Foams for Wound Care. Funded $38,703 (6/14-9/14). 2014 Sponsored Research Agreement with the Cranberry Institute; Cranberry Polyphenols and Gut Health: Integrated Cranberry Health Research at UW-Madison. Funded $67,494 (6/2014-5/15) 2014 Equipment Purchase Agreement with Johnsonville; Funded $87,000 (1/2014) 2014 Sponsored Research Agreement with Johnsonville; Extraction and Characterization of Antimicrobial Proteins and Peptides from Animal By-products. Funded $289,000 (1/2014-12/15) 2013 Standard Service Agreement with Recombinetics; Interaction between Diet and Genetics. Funded $68,000 (12/13-4/14) 2013 Standard Service Agreement with Cardiovascular Research Foundation; Induction of Atherosclerotic Lesion. Funded $36,000 (8/13) 2013 Sponsored Research Agreement with the Cranberry Institute; Cranberry Polyphenols and Gut Health: Integrated Cranberry Health Research at UW-Madison. Funded $50,000 (6/2013-5/14) 2013 Standard Service Agreement with Recombinetics; Analysis of Atherogenesis in Swine. Funded $43,000 (12/13-4/14) 2012 USDA / OREI; Forage-based Parasite Control in Sheep and Goats in the Northeast U.S. (Sub- Contract, James Kotcon, University of West Virginia). Funded $199,213 (10/2012-9/17) 2012 UW Graduate School TIF; Addition of Tannin Formulation to Enteral Nutrition to Counteract Impairment of or Improve Immune Function. Funded $50,000 (7/2012-6/13) 2012 Sponsored Research Agreement with the Cranberry Institute; Cranberry Polyphenols and Gut Health: Integrated Cranberry Health Research at UW-Madison. Funded $50,000 (6/2012-5/13) 2012 Sponsored Research Agreement with Johnsonville; Extraction and Characterization of Antimicrobial Proteins and Peptides from Animal By-products. Funded $50,000 (7/2012-6/13) 2011 Hartland Foundation (Sub-contract, Josh Medows – UW Madison- Neurosurgery); Intracranial Pressure Transducer. Funded $72,000 (7/2011 – 6/13) 2011 Sponsored Research Agreement with the Cardiovascular Research Foundation; Development of the Familial Hypercholesterolemic (FH) swine as a translational model for cardiovascular device and imaging research. Funded $345,000 (6/2011 – 5/14) 2011 UW Graduate School Industrial & Economic Development Research (IEDR); Supercritical fluid extraction of bioactive compounds from cranberries. Funded $50,000 (7/2011 – 6/12) 2011 Standard Service Agreement with ESO Technologies; Esophageal probe for cardiac monitoring. Funded $15,000 (1/2011 – 10/11) 2011 UW Graduate School TIF; Tannin-Chitosan composites inhibit E coli colonization in in vivo mouse model. Funded $50,000 (7/2011 – 6/12) 2011 Standard Service Agreement with International Cardio Corporation (formerly – Dutch Cardio, LLC.) to validate High Intensity Focused Ultrasound (HIFU) Technology ( Funded $90,000 ). 2010 Standard Service Agreement with International Cardio Corporation (formerly – Dutch Cardio, LLC.) to validate High Intensity Focused Ultrasound (HIFU) Technology ( Funded $180,000 ). 2008 Sponsored Research Agreement with the Cardiovascular Research Foundation; Development of the Familial Hypercholesterolemic (FH) swine as a translational model for cardiovascular device and imaging research. Funded $250,000 (6/2008 – 5/11)

PUBLICATIONS / PRESENTATIONS:

BOOK CHAPTERS 1. Seeram, N.P., Zhang Y., Reed J.D., Krueger C.G ., Yaya J. Pomegranate Phytochemicals. In Pomegranates (Medicinal and Aromatic Plants - Industrial Profiles). Editors: Seeram, N.P., Schulman, R.N. and Heber D. 2006; 3-30.

2. Krueger, C.G. , M.M. Vestling and J.D. Reed. Matrix-assisted laser desorption/Ionization time-of-flight mass spectrometry of anthocyanin-polyflavan-3-ol polymers in cranberry fruit [ Vaccinium macrocarpon , Ait.] and spray dried cranberry juice. ACS Symposium, Uncovering the Mysteries of Red Wine Pigments. 2004;886:232-246. 3. Reed, J. D., C. Krueger , G. Rodriguez, and J. Hanson. Secondary plant compounds and forage evaluation. In: Forage Evaluation in Ruminant Nutrition (D. I. Givens, E. Owen, R. F. E. Axford and H. M. Omed). CABI Publishing, Wallingford. 2000;433-448.

JOURNAL PUBLICATIONS

1. Madrigal-Carballo S, Hass L, Vestling MM, Krueger CG , Reed JD. Non-Covalent Pomegranate ( Punica granatum ) hydrolyzable tannin-protein complexes modulate antigen uptake, processing and presentation by a T-cell hybridoma line co-cultured with murine peritoneal macrophages. International Journal of Food Sciences and Nutrition . 2016; 12:1-9. PMID:27406472 2. Blumberg JB, Basu A, Krueger CG , Lila MA, Neto C, Novotny JA, Reed JD, Rodriguez-Mateos A, Tooner CD. The impact of cranberries on gut microbiota and cardiometabolic health: Proceedings of the Cranberry Health Research Conference 2015. Advances in Nutrition . 2016; 7 (Suppl):763S-770S. 3. Polewski, MA, Krueger CG , Reed JD, Leyer G. Ability of probiotics and/or cranberry proanthocyanidins to inhibit in vitro invasion of gut epithelial cells by extra-intestinal pathogenic E. coli. J. Functional Foods. 2016; 25:123-134. 4. Krueger, C.G. , N. Chesmore, X. Chen, J. Parker, C. Khoo, J. Marais, D. Shanmuganayagam, P. Crump, J.D. Reed. Critical reevaluation of the 4-(dimethylamino)cinnamaldehyde assay: Cranberry proanthocyanidin standard is superior to procyanidin A2 dimer for accurate quantification of proanthoccyanidins in cranberry products. J. Functional Foods. 2016; 22:13-19 5. Porras, A.M., D. Shanmuganayagam, J.J. Meudt, C.G. Krueger , T.A. Hacker, P.S. Rahko, J.D. Reed, K.S. Masters. Rapacz Familial Hypercholesterolemic Swine Develop Early Aortic Valve Disease. Journal of the American Heart Association . 2015; 4 (10): 1-13. PMID: 26508741 6. Feliciano, R.P., C.G. Krueger , J.D. Reed. Methods to determine relationships between structure and anti-microbial activity of cranberry proanthocyanidins. Molecular Nutrition and Food Research . 2015; 59(7); PMID: 25917127 7. Porras, A.M., D. Shanmuganayagam, J.J. Meudt, C.G. Krueger , J.D. Reed, K.S. Masters. Gene expression profiling of valvular interstitial cells in Rapacz familial hypercholesterolemic swine. Genom. Data. 2014; 2: 261-263 8. Rodriguez-Mateos, A.R., D. Vauzour, C.G. Krueger , D. Shanmuganayagam, J.D. Reed, L. Calani, P. Mena, D. Del Rio, A. Crozier. Flavonoids and related compounds, bioavailability and impact on human health: an update. Archives of Toxicology . 2014; 88: 1803-1853 9. Chen, X., J. Parker, C.G. Krueger , D. Shanmuganayagam, J. D. Reed. Validation of HPLC assay for identification and quantification of anthocyanins in black currants. Analytical Methods . 2014: 6; 8141-8147 10. Johnson, L.J., Y. Tekabe, M. Kollaros, G. Eng, K. Bhatia, C. Li, C.G. Krueger , D. Shanmuganayagam, A.M Schmidt. Imaging RAGE expression in atherosclerotic plaques in hyperlipidemic pigs. EJNMMI Research . 2014;4:26 11. Feliciano, R.P., J.A. Heintz, C.G. Krueger , M.M. Vestling, J.D. Reed. Fluorescent labeling of cranberry proanthocyanidins with 5-([4,6-dichlorotriazin-2-yl]amino)fluorescein (DTAF). Food Chemistry . 2015; 166:337-345 12. Feliciano, R., J. Meudt, D. Shanmuganayagam, B. Metzger, C.G. Krueger , J. D. Reed. Supercritical fluid extraction, cranberry proanthocyanidins, an enterocyte invasion by extra-intestinal pathogenic Escherichia coli. J Agric. Food Chem. 2014; 62:7730-7737 13. Wentland, A.L., O. Wieben, D. Shanmuganayagam, C.G. Krueger , J. J. Meudt, D. Consigny, L. Rivera, P.E. McBride, J.D. Reed, T.M Grist. Measurements of wall shear stress and aortic pulse wave velocity in swine with familial hypercholesterolemia. Journal of Magnetic Resonance Imaging. 2015; 41(5): 1475-85. PMID: 24964097 14. Tellez, A., P.S. Seifert, E. Donskoy, N. Sushkova, D.E. Pennington, K. Milewski, C.G. Krueger , G.L. Kaluza, M.J. Eppihimer, B. A. Huibregtse, K. D. Dawkins, J. F. Granada. Experimental evaluation of efficacy and healing response of Erolimus eluting stents in the familial hypercholesterolemic swine model: A comparative study of bioabsorbable versus durable polymer stent platforms. Coronary Artery Disease . 2014; 25:198-207 15. Cheng, D.M., N. Pogrebnyak, P. Kuhn, C.G. Krueger , W.D Johnson and I. Raskin. Development and phytochemical characterization of highpolyphenol red lettuce with anti-diabetic properties. PLOS One . 2014;9:3

16. Pierre, J.F, A.F. Heneghan, R.P. Feliciano, D. Shanmuganayagam, C.G. Krueger , J.D. Reed, K.A. Kudsk. Cranberry proanthocyanidins improve intestinal sIgA during elemental enteral nutrition. Journal of Parenteral and Enteral Nutrition. 2014; 38:107-114. PMID 23359014 17. Burleigh, A.E., S.M. Benck, S.E. McAchran, J.D. Reed, C.G. Krueger and W.J. Hopkins. Consumption of sweetened, dried cranberries may reduce urinary tract infection incidence in susceptible women – a modified observational study. Nutrition Journal . 2013;12:139 18. Feliciano, R.P., J.J. Meudt, D. Shanmuganayagam, C.G. Krueger and J.D. Reed. Ratio of “A-type” to “B-type” proanthocyanidin interflavan bonds affects extra-intestinal Pathogenic Escherichia coli invasion of gut epithelial cells. J Agric Food Chem . 2013; Web Publication (DOI: 10.1021/jf403839a) 19. Roopchand, D.E., P. Kuhn, C.G. Krueger , K. Moskal, M.A. Lila and I. Raskin. Concorde grape pomace polyphenols complexed to soy protein isolate are stable and hypoglycemic in diabetic mice. J Agric Food Chem . 2013; Web Publication (DOI:10.1021/JF403238e). 20. Roopchand, D.E., C.G. Krueger , K. Moskal, B. Fridlender, M.A. Lila and I. Rashkin. Food-compatible method for the efficient extraction and stabilization of cranberry pomace polyphenols. Food Chemistry . 2013; 141:3664-3669. PMID: 21. Bahls, M., C.A. Bidwell, J. Hu, A. Tellez, G.L. Kaluza, J.F. Granada, C.G. Krueger , J.D. Reed, M.H. Laughlin, W.G. Van Alstine and S.C. Newcomer. Gene expression differences during the heterogeneous progression of peripheral atherosclerosis in familial hypercholesterolemic swine. BMC Genomics . 2013; 14:443 22. Krueger, C.G. , J.D. Reed, R.P. Feliciano, A.B. Howell. Quantifying and characterizing proanthocyanidins in cranberries in relation to urinary tract health. Analytical and Bioanalytical Chemistry . 2013; 405:4385-4395. PMID: 23397091 23. Pierre, J.F, A.F. Heneghan, J.M. Meudt, M.P. Shea, C.G. Krueger , J.D. Reed D., K.A. Kudsk Shanmuganayagam. Parenteral nutrition increases susceptibility of ileum invasion by E. coli . Journal of Surgical Research. 2013; 183:583-591. PMID: 23481564 24. Pierre, J.F, A.F. Heneghan, R.P. Feliciano, D. Shanmuganayagam, D.A. Roenneburg, C.G. Krueger , J.D. Reed, K.A. Kudsk. Cranberry proanthocyanidins improve the gut mucous layer morphology and function in mice receiving elemental enteral nutrition. Journal of Parenteral and Enteral Nutrition. 2013; 37:401-409. PMID: 23064255 25. Milewski, K., M.E. Afari, A. Tellez, M.S. Aboodi, J. Kim, Y. Cheng, G.B. Conditt, J.C. McGregor, G.H. Yi, M. Stenoien, C.G. Krueger , G. Kaluza, J.F. Granada. Evaluation of Efficacy and Dose Response of Different Paclitaxel Coated Balloon Formulations in a Novel Swine Model of Ilio-Femoral In-Stent Restenosis. JACC Cardiovascular Interventions . 2012; 5:1081-1088. PMID: 23078739 26. Ge, W., C.G. Krueger , A. J. Weichmann, D. Shanmuganayagam, T. Varghese. Displacement and strain estimation for evaluation of arterial wall stiffness using a familial hypercholesterolemia swine model of atherosclerosis. Medical Physics. 2012; 39:4483. PMID 22830780. 27. Feliciano, R.P., C.G. Krueger , D. Shanmuganayagam, M. M. Vestling, J. D. Reed. Deconvolution of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry isotope patterns to determine ratios of A-type to B-type interflavan bonds in cranberry proanthocyanidins. Food Chemistry . 2012; 135:1485-1493. PMID: 22953884 28. Feliciano, R.P., M.P. Shea, D. Shanmuganayagam, C.G. Krueger , A.B. Howell, J.D. Reed. Comparison of Isolated Cranberry (Vaccinium macrocarpon Ait.) Proanthocyanidins to Catechin and Procyanidins A2 and B2 for Use as Standards in the 4-(Dimethylamino)cinnamaldehyde Assay. J Agric Food Chem . 2012; 60:4578-85. PMID: 22533362 29. Shanmuganayagam, D., M. Beahm, M. Kuhns, C.G. Krueger , J. Reed, J. Folts. Differential effects of grape (Vitis vinifera) skin polyphenolics on human platelet aggregation and low-density lipoprotein oxidation. J Agric Food Chem. 2012; 60:5787-5794. PMID: 22224546 30. Granada, J.F., M, Krzysztof, H. Ahao, J.J. Stankus, A. Tellez, M.S. Aboodi, G.L. Kaluza, C.G. Krueger , R. Virmani, L.B. Schwartz, A Nikanorov. Vascular response to Zotarolimus-coated balloons in injured superficial femoral arteries of the familial hypercholseterolemic swine. Circ Cardiovasc Interv . 2011;4:447-455. PMID: 21953371 31. Bahls, M., C.A. Bidwell, J. Hu, C.G. Krueger , J.D. Reed, A. Tellez, G.L. Kaluza, J.F. Granada, W.G. Van Alstine, S.C. Newcomer. Gene expression differences in healthy brachial and femoral arteries of Rapacz familial hypercholesteroemic swine. Physiol Genomics. 2011 ;43:781-788.

32. Tellez, A., C.G. Krueger , P. Seifert, D. Winsor-Hines, C. Piedrahita, Y. Cheng, K. Milewski, M.S. Aboodi, G. Yi, J.C. McGregor, T. Crenshaw, J. Reed, B. Huibregtse, G.L. Kaluza, J.F. Granada. Coronary bare metal stent implantation in homozygous LDL receptor deficient swine induces a neointimal formation pattern similar to humans. Atherosclerosis . 2010;213:518-524. 33. Madrigal-Carballo, S., G. Rodriguez, C.G. Krueger , J.D. Reed. Evaluation of Costa Rican traditional fruits as potential sources of natural polyphenolic antioxidants and antimicrobials. Inventi Impact: Nutraceuticals. 2010;1:2. 34. Madrigal-Carballo S., S. Lim, G. Rodriguez, , A.O Vila, C.G. Krueger, S. Gunasekaran, J.D. Reed. Biopolymer coating of soybean lecithin liposomes via layer-by-layer self-assemply as novel delivery system for ellagic acid. J. Functional Foods. 2010;2: 99-106. 35. Staub, D., A.F.L. Schinkel, B. Coll, S. Coli, A.F.W. van der Steen, J.D. Reed, C.G. Krueger , K.E. Thomenius, D. Adam, E.J. Sijbrands, F.J. ten Cate and S.B. Feinstein. Contrast-enhanced Ultrasound Imaging of the Vasa Vasorum: From early Atherosclerosis to the identification of unstable plaques. JACC Imaging . 2010; 3;761-771. 36. Schrinkel, A.F.L., C.G. Krueger , A. Tellez, J.F. Granada, J.D. Reed, A. Hall, W. Zang, C. Owens, G.L. Kaluza, D. Staub, B. Coll, F.J. ten Cate and S.B. Feinstein. Contrast-enhanced ultrasound for imaging vasa vasorum: comparision with histopathology in a swine model of atherosclerosis. Eur J Echocardiogr . 2010;11:659-664. 37. Madrigal-Carballo S., G. Rodriguez, C.G. Krueger , M. Dreher, J.D. Reed. Pomegranate ( Punica granatum ) supplements: Authenticity, antioxidant and polyphenol composition. J. Functional Foods. 2009;1:324-329. 38. Kuffa M., T.J. Priesbe, C.G. Krueger , J.D. Reed, M. Richards. Ability of dietary antioxidants to affect lipid oxidation of cooked turkey meat in a simulated stomach and blood lipids after a meal. J. Functional Foods. 2009;1:208-216. 39. Martin KR, Krueger CG , Rodriguez G, Dreher M, Reed JD. Development of a novel pomegranate standard and new method for the quantitative measurement of pomegranate polyphenols. J Agric Food Chem. 2009; 89:157-62. 40. Larrain, R.E., Krueger, C.G ., Richards, M.P., Reed, J.D. Color changes and lipid oxidation in pork products made from pigs fed with cranberry juice powder. J. Muscle Foods . 2008;19: 17-33. 41. Shanmuganayagam D., Warner T., Krueger C. , Reed J., Folts J. Concord grape juice attenuates platelet aggregation, serum cholesterol and development of atheroma in hypercholesterolemic rabbits. Athersoclerosis . 2007;190:135-142. 42. Neto C.C. Krueger C.G. , Lamoureaux T.L., Kondo M., Vaisberg A.J., Haurta R.A.R., Curtis S., Matchett M.D., Yeung H., Sweeney M.I., Reed J.D. MALDI-TOF MS characterization of proanthocyanidins from cranberry fruit (Vaccinium macrocarpon) that inhibit tumor cell growth and matrix metalloproteinase expression in vitro. J. Sci. Food Agric . 2006;86:18-25. 43. Lee C.H., Krueger C.G. , Reed J.D., Richards M.P. Inhibition of hemoglobin-mediated lipid oxidation in washed fish muscle by cranberry components. Food Chem . 2006;99:591-599. 44. Reed J.D., Krueger C.G ., Vestling M.M. MALDI-TOF Mass spectrometry of oligomeric food polyphenols. Phytochem . 2005;66 2248-2263. 45. Howell A.B., Reed J.D., Krueger C.G. , Winterbottom R., Cunningham D.G., Leahy M. A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity. Phytochem . 2005;66:2281-2291. 46. Afaq F., Saleem M., Krueger C.G ., Reed J.D., Mukhtar H. Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice. Int. J. Cancer. 2005;113:423-433. 47. Krueger, C.G .; Vestling, M.M.; Reed, J.D. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of heteropolyflavan-3-ols and glucosylated heteropolyflavans in sorghum [ Sorghum bicolor (L.) Moench)]. J. Agric. Food Chem . 2003;53:538-543. 48. Shanmuganayagam, D.; Beahm, M.R.; Osman, H.E.; Krueger, C.G .; Reed, J.D.; Folts, J.D. Grape seed and grape skin extracts elicit a greater antiplatelet effect when used in combination than when used individually in dogs and humans. J. Nutrition. 2002;132:3592-3598. 49. Porter, M. L., C. G. Krueger , D. A. Wiebe, D. G. Cunningham, and J. D. Reed. Cranberry proanthocyanidins associate with low-density lipoprotein and inhibit in vitro Cu 2+ -induced oxidation. J Sci Food Agric. 2001;81:1306-1313. 50. Hedqvist, H., I. Mueller-Harvey, J. D. Reed, C. G. Krueger , and M. Murphy. Characterisation of tannins and in vitro protein digestibility of several Lotus corniculatus varieties. Animal Feed Science and Technology. 2000;87:41-56.

51. Krueger, C. G. , N. C. Dopke, P. M. Treichel, J. Folts, and J. D. Reed. Matrix-assisted laser desorption/ionization time- of-flight mass spectrometry of polygalloyl polyflavan-3-ols in grape seed extract. J Agric Food Chem. 2000;47: 3693- 3701. 52. Krueger, C. G. , K. A. Albrecht, J. D., Reed, E. J. Bures, and V. N. Owens. Sodium sulfite effects on recovery and composition of detergent fiber and lignin from forage legumes varying in levels of proanthocyanidins. J Sci Food Agric. 1999;79: 1351-1356.

ABSTRACTS, ORAL AND POSTER PRESENTATIONS 1.

Barone, C, S. Ferguson, A.M. Zajac, R. Brown, J. Reed, C. Krueger , K. Petersson. In vitro screening of antihelmintic efficacy of birdsfoot trefoil commercial varieties and cultivars against ovine Haemonchus contortus. Joint Annual Meeting Animals and Science. July 19-23, 2016. 2. Krueger, CG ., Alfro-Viquez E, Madrigal-Carballo S, Reed JD. Tannin-chitosan composite nanoparticles as an alternative to antibiotics. 249 th American Chemical Society National Meeting. March 22, 2015, Denver, CO. Oral Presentation. 3. Porras A, Shanmuganayagam D, Meudt JJ, Krueger CG, Rahko P, Reed JD, Masters K. Investigating Rapacz familial hypercholesterolemic swine as a potential model of calcific aortic valve disease. Presented at the 5th National Heart, Lung, and Blood Institute (NHLBI) Symposium on Cardiovascular Regenerative Medicine (2013), September 25-26, Bethesda, Maryland. 4. Johnson, L.L, Y. Tekabe, M. Kollaros, G. Eng, K. Bhatia, R.B. Groner, C.G. Krueger . Atherosclerosis and RAGE expression by histology and imaging in hyperlipidemic pigs. Atherosclerosis, Thrombosis and Vascular Biology sessions of the American Heart Association Meeting , May 1-3, Lake Buena Vista, FL. 5. Krueger CG , Meudt JJ, Howell AB, Khoo C, Shanmuganayagam D, Reed JD. Consumption of cranberry powder shifts urinary protein profile in healthy human subjects. Experimental Biology 2013 Meeting , April 20–24, Boston, MA. 6. Cheng, D.M., N. Pogrebnyak, A. Poulev, P. Kuhn, C.G. Krueger , C. Waterman, I. Raskin. Antidibetic effects and antioxidant capacity of polyphenol-enhanced Rutgers Scarlet Lettuce. Experimental Biology 2013 Meeting , April 20– 24, Boston, MA. 7. Krueger, C.G ., D. Shanmuganayagam, S. Madrigal-Carballo, E. Zeldin. Applications of tannin-chitosan composite nanoparticles for improved food quality and safety. Abstracts of Papers of The American Chemical Society. 245; 74- AGFD. April 7, 2013, New Orleans, LA. Oral Presentation. 8. Reed, J.D., J.F. Fierre, C.G. Krueger, D. Shanmuganayagam and K.A. Kudsk. Food polyphenols and gut health. Abstracts of Papers of The American Chemical Society. 245; 249-AGFD. April 7, 2013, New Orleans, LA. Oral Presentation. 9. Shanmuganayagam D, Johnson RE, Meudt JJ, Feliciano RP, Kohlmann KL, Nechyporenko AV, Heinz J, Krueger CG , Reed JD. A-type proanthocyanidins from cranberry inhibit the ability of extraintestinal pathogenic E. coli to invade gut epithelial cells and resist killing by macrophages. Experimental Biology 2013 Meeting , April 20–24, Boston, MA. 10. Wentland AL, Grist TM, Shanmuganayagam D, Krueger CG , McBride PE, Meudt JJ, Reed JD, Wieben O. Evaluation and Validation of Pulse Wave Velocity Measurements from 2D and 4D PC MRI in Swine with Familial Hypercholesterolemia: Initial Results. International Society for Magnetic Resonance in Medicine 21 st Annual Meeting & Exhibition , April 22-26, 2013, Salt Lake City, Utah. 11. Reed, JD, Pierre, JF, Krueger CG , Shanmuganayagam D, Kudsk KA. Food polyphenols and gut health. The 245 th American Chemical Society National Meeting & Exposition , April 7-11, 2013, New Orleans, LA. Oral presentation. 12. Feliciano. R.P., C.G Krueger , M.M. Vestling and J.D. Reed. Deconvolution of MALDI-TOF MS isotope patterns to determine ratios of cranberry to apple proanthocyanidin extracts in binary mixtures. American Society of Mass Spectrometry Asilomar Conference on Mass Spectrometry in Food Safety and Quality, Pacific Grove, CA, October 5-9, 2012. Poster and Poster Highlight oral presentation. 13. Feliciano, R.P., C.G. Krueger , D. Shanmuganayagam, M.M. Vestling and J.D. Reed. Deconvolution of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry isotope patterns to determine ratios of A-type to B-type interflavan bonds in cranberry proanthocyanidins. XXVIth International Conference on Polyphenols. Florence, Italy, July 22-26, 2012. Poster Presentation.

14. Afari, M.E., K. Milewski, A. Tellez, M.S. Aboodi, J. Kim, Y. Cheng, G.B. Conditt, J.C. Mcgregor, G.H. Yi, M. Stenoien, D, Laganki, C.G. Krueger , G.L. Kaluza, J.F. Granada. Evaluation of Efficacy and Dose Response of Different Paclitaxel Coated Balloon Formulations in a Novel Swine Model of Ilio-Femoral In-Stent Restenosis. The 61 st Annual Scientific Session of the American College of Cardiology. Chicago, IL, 2012. Poster. 15. Pierre JF, Heneghan AF, Feliciano RP, Shanmuganayagam D, Roennburg DA, Krueger CG , Reed JD, Kudsk KA. Addition of proanthocyanidins to intra-gastric elemental nutrition stimulates intestinal goblet cell size and function. Presented at 32 nd Annual Meeting of the Surgical Infection Society–North America , April 18-21, 2012, Dallas, TX. 16. Pierre JF, Heneghan AF, Feliciano RP, Shanmuganayagam D, Roennburg DA, Krueger CG , Reed JD, Kudsk KA. Cranberry proanthocyanidins attenuate the effects of elemental enteral nutrition on size, density and function of intestinal goblet cells in mice. Presented at Third Annual University of Wisconsin Department of Surgery Research Summit: Health Services, Outcomes and Clinical Research , January 11, 2012, Madison, WI. 17. Smiltneek, A.J., C.G. Krueger , A.M. Weichmann, R.J. Colman, J.D. Reed, D. Shanmuganayagam. Adiposity-induced dysfunction of glucoregulation ins swine model of childhood obesity and cardiovascular disease. Swine in Biomedical Research. Chicago, IL, July 17-19, 2011. Poster. 18. Shanmuganayagam, D., C.G. Krueger , A. Tellez, J.F. Granada, J.D. Reed. A validated swine model of cardiovascular disease for basic, translational and preclinical research. Swine in Biomedical Research. Chicago, IL, July 17-19, 2011. Poster. 19. Richards MP, Smiltneek AJ, Shanmuganayagam D, Krueger CG , Crenshaw TD, Reed JD. Effect of obesity on in vitro hemolysis using familial hypercholesterolemic swine. Presented at the 34 th Steenbock Symposia: The Metabolism of Lipids: Implications in Human Diseases , May 22-25, 2011, Madison, WI. 20. Tellez, A., Krueger, C.G. , Aboodi, M.S., Cheng, Y.P., Inami, S., Yi, G.H., McGregor, J., Crenshaw, T., Reed, J.D., Kaluza ,G.L., Granada, J.F. The Homozygous LDL Receptor Deficient Swine Predicts Efficacy Following DES Implantation: A Prospective Endovascular Imaging Feasibility Study. Journal of the American College of Cardiology . 53(10):A7-A7; Suppl.1. March 10, 2009 21. Tellez A, Cheng YP, Milewski K, Huibregtse BA, Winsor-Hines D, Seifert PS, Krueger CG , Thim T, Wallace-Bradley D, Aboodi M, Yi GH, Conditt GB, Crenshaw T, Reed JD, McGregor JC, Flynn A, Ordanes D, Kaluza GL, Granada JF. Long-term patterns of neointimal formation following bare metal stents in the LDL receptor deficient swine: and OCT-histology correlation study. 2009. American Journal of Cardiology . 104 (6A) 62D-63D. 22. Tellez A, Schinkel AFL, Krueger CG , Reed JD, Hall A, Zang W, Owens C, Staub D, Coll B, Kaluza GL, Granada JF, Feinstein SB. Vasa Vasorum correlates with arterial intima-media thickening in a large model of complex peripheral atherosclerosis: a histology and contrast-enhanced ultrasound correlation study. 2009. American Journal of Cardiology . 104 (6A) 75D-75D. 23. Coll, Blai, Sokulin A, Adam D, Mazzone T, Meyer P, Zang W, Hall A, Owen C, Krueger C , Reed J, Thomenius K, Perez A, Biederman B, Feinstein S.Contrast-enhanced carotid ultrasound Vasa Vasorum inversely correlates to HDL- cholesterol concentration in 324 type 2 diabetes mellitus patients. Arter. Throm. Vascular Bio. 28 (6):E66-E66, P177. 2008 24. Krueger, C.G ., Reed, J.D., Vestling, M.M., Howell, A. B. Characterizing cranberry proanthocyanidins that promote urinary tract health. USDA NRI Project Director Meeting, New Orleans, LA. June 27-28, 2008. Poster Presentation 25. Madrigal-Carballo, S., Krueger, C.G ., Haas, L.G., Reed, J.D. Cranberry proanthocyanidin complexes with bovine serum albumin attenuate the bacterial lipopolysaccharide induced expression of iNOS and COX-2 in Raw 264.7 macrophages. Phytochemical Society of North America annual Meeting, Pullman, WA, June 25-29, 2008. Poster Presentation. 26. Madrigal-Carballo, S., Dettlof, M., Rodriguez, G., Krueger, C.G ., Dreher, M., Reed, J.D.Antioxidant capacity and polyphenol composition of pomegranate ( Punica granatum ) dietary supplements. Phytochemical Society of North America annual Meeting, Pullman, WA, June 25-29, 2008. Poster Presentation. 27. Coll, B., Sokulin, A., Adam, D., Mazzoni, T., Meyer, P., Zang, W., Hall, A., Owen, C., Krueger, C. , Reed, J., Thomenius, K., Perez, A., Feistein, S. Contrast enhanced carotid ultrasound vasa vasorum inversely correlates to HDL cholesterol concentration in 324 type 2 diabetes mellitus patients. The 57 th Annual Scientific Session of the American College of Cardiology. Chicago, IL, March 29-April 1, 2008. 28. Neto, C. C., Liberty, A. M., Amoroso, J. W., Hart, P. E., Krueger, C ., MacLean, M. A., Hurta, R. A. R. Cranberry Phytochemicals: Structure and in vitro Anti-Cancer Activities. The 48 th Annual Meeting of the American Society of Pharmacognosy, Portland, ME, July, 2007.