ESTRO Brachytherapy for Prostate Cancer 2018

1940: Canadian born Charles Huggins recognized the androgen dependence of PCA

ADT

1966: nobel price for medecine: discoveries concerning hormonal treatment of PCA

1997: Zietman: the combination of radiation with orchiectomy for Shionogi tumors treated in vitro resulted in significant increase in control Now, several large national and international RCT’s confirmed and quantified the therapeutic benefit of ADT in combination with EBRT

Wolff FR et al: Eur J Cancer, 2015;51:2345-2367