ESTRO Brachytherapy for Prostate Cancer 2018

Even short term ADT gives an absolute increase 5,3% at 10 years ! (Kobutek et al)

Re-analysis of 6 RCTs (Albertsen et al )

- the increase in cardio-vascular mortality and morbidity might be an LHRH agonist class effect - significantly less CVD events in men treated with LHRH antagonists vs LHRH agonists (HR: 0,44 - 95% CI 0,26-0,74 - p=0,002)

Pronounce NCT02663908: RCT comparing major CV events with LHRH agonists vs antagonists in patients with pre-existing CV morbidity

Kobutek et al, Int J Radiat Oncol Biol Phys 2014;90:S15 Albertsen et al, Eur Urol 2014;65:565-573