ESTRO Brachytherapy for Prostate Cancer 2018

Sildenafil Restores Erection Hardness (ICP)

Sildenafil l

100

ICP Reduced

ICP Restored

80

60

40

0 ICP, mmHg Blood Flow, ml/min 20 0 100 200

Nerve stim

60s

Cuff

Cuff

• Penile blood flow restriction reduces cavernous nerve-stimulated increases in ICP • Sildenafil restores erection hardness to control levels

Preclinical model

Wayman C et al. ESSM. 4-7 December 2005. Poster M-05-141.