SBRT2015

Dose de-escalation

Prospective Phase II trial Iyenger JCO 2014 • Maximum 5 Platin-resistant sites based on FDG-PET

• SBRT to all progressive sites, • Switch to concurrent Erlotinib

• 24 patients with 52 sites

1 Fx

3 Fx

5 Fx

In-field failure

3 / 21

Physical dose

19 – 24Gy 27 – 33Gy 35 – 40Gy

Out-field failure

10 / 21

Max BED

82Gy

70Gy

72Gy

No failure

10 / 21

 Excellent OS of 20.4 months in Platinum-resistant stage NSCLC DESPITE lower irradiation doses

/ Matthias Guckenberger - DEGRO 2015

29.08.2015

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