SBRT2015

Normal tissue tolerance

Re-irradiation tolerance and recovery

Skin & mucosa

Small intestine

Mesechymal

Bone

Full – partial

Partial

Partial

Partial

Lung pneumonitis Lung fibrosis

Heart

Bladder

Kidney

Full – partial

No

No

No

No

Factors associated with recovery: • Initial biological dose in relationship to tolerance dose • Initial volume irradiated • Time interval between treatment courses

SBRT for re-irradiation

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