PracticeUpdate Neurology Best of 2018

CONTENTS 3

EDITOR’S PICKS 8 Discontinuation of Disease-Modifying Therapy in Patients With Multiple Sclerosis Over Age 60 Comment by Benjamin Segal MD 9 Thrombectomy for Stroke at 6 to 16 Hours With Selection by Perfusion Imaging Comment by Jean-Claude Baron MD, ScD, FMedSci 10 Zonisamide as an Adjunct to Levodopa for DLB Parkinsonism Comment by Mark Hallett MD 11 Differentiating Myelitis From Vascular and Other Causes of Myelopathy 11 Restarting Antiplatelet Therapy After Spontaneous Intracerebral Hemorrhage 12 Tenecteplase vs Alteplase Before Thrombectomy for Ischemic Stroke Comment by James C. Grotta MD 13 Complete Detoxification Is the Most Effective Treatment of Medication- Overuse Headache 14 Statin-Associated Muscle Disease 14 Emergency Department Neuroimaging for Epileptic Seizures 15 Effect of Modified Atkins Diet in Adults With Drug-Resistant Focal Epilepsy Comment by Amal Satte MD 16 Effect of Standard vs

TOP STORIES 2018 5 Gene Therapy is Here By Mark Hallett MD 6 Neuromuscular Diseases: Hereditary Transthyretin Amyloidosis By Marinos C. Dalakas MD 6 Stroke: The DEFUSE 3 Trial By Argye Elizabeth Hillis MD, MA 7 FDA Approval of Cannabidiol for Use in

Lennox-Gastaut and Dravet Syndromes By Nina F. Schor MD, PhD

Intensive Blood Pressure Control on Cerebral Blood Flow in Small-Vessel Disease Comment by Argye Elizabeth Hillis MD, MA

CONFERENCE

18 International Stroke Conference 2018 By the PracticeUpdate Editorial Team 17 Functional Neurological Disorders in Parkinson’s Disease 18 Training Emergency Medical Service Staff in Simple Test Helps Improve Identification of Posterior Stroke 19 Combination Medication Reduces Stroke by 44% in Patients With Only Moderate Risk Profile 20 COMPASS Study Identifies Massive Gaps in Stroke Rehabilitation Care

21 2018 Annual Meeting of the American Academy of Neurology By the PracticeUpdate Editorial Team 21 Eptinezumab Effective for Preventing Frequent Episodic Migraine 22 Cancer Commonly Comorbid With Stroke 22 New Method of Monitoring Multiple Sclerosis Effective and 10 Times Less Expensive Than Conventional MRI 23 Antiepileptic Treatment Maintains Seizure Freedom During Pregnancy and Postpartum Period

24 15th International Congress on Neuromuscular Diseases By the PracticeUpdate Editorial Team 24 Ultrasonography Valuable in Confirmation of Carpal Tunnel Syndrome 25 Some Neuromuscular Diseases Linked to Malignant Hyperthermia or Similar Reactions 26 Thymectomy Continues to Be Successful for Myasthenia Gravis

VOL. 3 • NO. 4 • 2018