IMRT Course 2016

Second Malignancies

Hall et al. ( IJROBP 2003 ) IMRT may increase second malignancy rate from 1% to 1.75% Higher MU’s, increased leakage resulting in increase body dose, larger volume of normal tissue receiving a lower dose But, most second malignancies seen in the moderate or high dose volume Paediatrics

- More sensitive to RT induced cancers

- Scattered radiation in small body

- Genetic susceptibility

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