SPIFAN Stakeholder Panel (March 14, 2018)

G uidelines for S tandard M ethod P erformance R equirements

AOAC O fficial M ethods of A nalysis (2016)

Appendix F, p. 6

Table A1. Performance requirements

Classifications of methods a

Quantitative method

Qualitative method

Main component b

Trace or contaminant c

Main component b

Trace or contaminant c

Identification method

Parameter Single-laboratory validation Inclusivity/selectivity Exclusivity/cross-reactivity Environmental interference Laboratory variance

Applicable range Bias d

Applicable range Bias d

Inclusivity/selectivity Exclusivity/cross-reactivity Environmental interference Laboratory variance

Inclusivity/selectivity Exclusivity/cross-reactivity Environmental interference

Precision Recovery Limit of quantitation (LOQ)

Precision Recovery LOQ

Probability of detection (POD) e

POD at AMDL f

Probability of identification (POI)

Reproducibility

RSD or target  measurement  uncertainty R

RSD or target measurement uncertainty R

POD (0) POD (c) Laboratory POD g

POD (0) POD (c) Laboratory POD g

POI (c)

Laboratory POI

a See Annex B for additional information on classification of methods. b  ≥100 g/kg. c  <100 g/kg. d  If a reference material is available. e  At a critical level. f  AMDL = Acceptable minimum detection level. g  LPOD = CPOD.

© 2016 AOAC INTERNATIONAL