AOAC_SPDS_ERP_-_Set_3

1. Are the definitions specified in the SMPR used and applied appropriately in the supporting documentation (manuscripts, method studies, etc...)? If not, please explain the differences and if the method is impacted by the difference. 2. Is there information demonstrating that the method meets the SMPR Method Performance Requirements using the Reference Materials stated in the SMPR? If not, then specify what is missing and how this impacts demonstration of performance of the method. method performs within the SMPR Method Performance Requirements using the Reference Materials stated in the SMPR? If not, then specify what is missing and how this impacts demonstration of method performance. 3. Is there information demonstrating that the method performs within the SMPR Method Performance REquirements table specifications for all analytes in the SMPR applicability statement? If not, please specify what is missing and whether or not the method's applicability should be modified. 1. Based on the supporting information, were there any additional steps in the evaluation of the method that indicated the need for any additional precautionary statements in the method? 4. Is there information demonstrating that the

Yes.

Yes. There is ample data to support the method requirements for reproducibility and accuracy.

Yes. The method performed within requirements for the three SRM's referenced in the SMPR.

Yes. There was one product that gave a slightly higher result than that for the upper limit for recovery %, but this was most likely due to the non-uniformity of the product.

There was an indication by the authors of the method that the recovery specifications from the SMPR were more stringent than those found in AOAC dietary supplement guidelines.