AOAC_SPDS_ERP_-_Set_3

2. Does the method contain system suitability tests or controls as specified by the SMPR? If not, please indicate if there is a need for such tests or controls and which ones. 3. Is there information demonstrating that the method system suitability tests and controls as specified in the SMPR worked appropriately and as expected? If no, please specify. 4. Based on the supporting information, is the method written clearly and concisely? If no, please specify the needed revisions. 5. Based on the supporting information, what are the pros/strengths of the method? 6. Based on the supporting information, what are the cons/weaknesses of the method?

Yes, system suitability is covered.

Yes, there is information supporting system suitability has been met per SMPR.

Method is clearly written. Would like to see data around LOQ/LOD. Also, there is a comment that centrifugation is used instead of filtration to prevent loss/binding of catechins to filters. Would like to see data in support of this.

The method provides a rapid way to quantify seven catechins and caffeine in green tea extracts, supplements, etc. The accuracy, linearity and selectivity is good.

The only weakness of this method is that it does not cover all of the analytes outlined in the SMPR.

7. Any general comments about the method?

Would like to see additional work to determine if the missing analytes could be added.

Do you recommend this method be adopted as a First Action and published in the Official Methods of Analysis of AOAC INTERNATIONAL? Please specify rationale.

Yes, if partnered with another method (TEA-01) for a more complete analysis of SMPR requirements.