Dose Course 2018_Flipping book

How to set the Clinical tolerance limit ( TL D )?

• Clinical tolerance limits or specifications should be based on clinical experience. • Clinical experience can be summarized through statistical analysis of the outcome of a particular treatment for a particular tumor disease. • Examples: • Local tumor control as a function of dose. • Fraction of survivors after five years as a function of dose. • At the same time, normal tissue complications must be taken into account.