Haematology 2018

Immune-related adverse events

• Grade 3 or higher irAEs are observed in 11–22% of patients

• LUNG : includes interstitial pneumonia, pneumonitis, • BOWEL colitis, gastrointestinal inflammation, stomatitis , increased alanine aminotransferase/aspartate aminotransferase levels, pancreatitis, • RENAL nephrotic syndrome, • PANCREAS fulminant type 1 diabetes mellitus, • BONE MARROW : myelodysplastic syndrome, leukopenia, thrombocytopenia, • OTHER : septic meningitis, pyrexia, infusion reaction, joint swelling, pain, tumor progression, and arrhythmia.