Haematology 2018

Targeting of normal B-cells CAR19 toxicity

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Duration correlates with persistence

▪ IVIg can be given to pts with persistent hypo- gammaglobulinaemia ▪ No serious infectious complications arising following this in trials reported to date ▪ Obtundation, cranial nerve palsy, aphasia, seizures

B-cell Depletion

Neuro- toxicity

▪ Not related to presence of CNS disease ▪ CSF pleocytosis – CAR+ and CAR- T cells ▪ Self-resolves within weeks

Immune Syndromes

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