Haematology 2018

NT Depleted

NT 5x2Gy RT +  B7-H1 10mg/kg 3qw 5x2Gy RT +  B7-H1 +  CD8 mAb 5x2Gy RT +  B7-H1 +  CD4 mAb 5x2Gy RT +  B7-H1 +  AGM1 mAb

CD8a

CD49b

100

80

60

CD4

40

CD49b

20

Percent survival

0

0

25

50

75

100

Time after tumour innoculation (days)

CD8a

CD49b

Efficacy of RT and anti-PD-L1 combination is CD8 + T cell dependent