Haematology 2018
Dendritic cell depletion abrogates the therapeutic effect of RT and anti-CD40 combinations S. J. Dovedi, G.L. Bhalla, S.A. Beers, E. J. Cheadle, L Mu, M.J. Glennie, T.M. Illidge, J. Honeychurch. (Cancer Immunol Res. 2016 Jul;4(7):621-30)
1 0 0
C o n tro l
DT
8 0
R T +
C D 4 0 m A b
R T +
C D 4 0 m A b + D T
6 0
- DT
+ DT CD11c depletion
4 0
2 0
P ercen t su rvival
*
0
0
2 0
4 0
6 0
8 0
1 0 0
T im e a f te r tu m o r im p la n ta t io n (d a y s )
1 0 0
8 0
6 0
C o n tro l
DT
4 0
R T +
C D 4 0 m A b
2 0
R T +
C D 4 0 m A b + D T
*
P e rc e n t s u rv iv al
100
0
0
2 0
4 0
6 0
8 0
80
T im e a f te r tu m o r im p la n ta t io n (d a y s )
60
40
1 0 0
n / s
8 0
20
6 0
0 Incidence of lymph node
C o n tro l
4 0
R T + T L R -7 a g o n is t
metastasis (% of treated cohort)
R T + T L R -7 a g o n is t + D T
2 0
Percent survival
R T + T L R -7 a g o n is t +
C D 2 0m A b
CD40 mAb
0
0
2 0
4 0
6 0
CD40 mAb + DT
RT +
T im e a f te r tu m o r im p la n ta tio n (d a y s )
RT +
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