Haematology 2018

HL treatment changes since 1965

Chemotherapy

Radiotherapy

Trend: ↓ dose alkylating

Trend: ↓ RT target volumes, ↓ RT dose

<1980

MOPP(like) & single agents

<1980

Classical fields

1980-1995 MOPP/ABVD; MOPP ABV

1980-1995

Classical fields; IFRT

>1995

ABVD; MOPP-ABV; EBVP; BEACOPP >1995

IFRT

>2012

Brentuximab-vedotin containing regimens >2006

INRT; ISRT

MOPP: Mechlorethamine, vincristine, procarbazine, prednison ABVD: Doxorubicin, bleomycin, vinblastine, dacarbazine ABV: Doxorubicin, bleomycin, vinblastine BEACOPP: Bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednison

Hodgson, ASH educational 2011