Haematology 2018

Breast cancer following HL a Dutch case-control study

Radiation dose in Gy (median)

Cases

Controls

OR†

95%CI

<4 (3.6)

9

47

1.0*

Ref

4-24 (15.5)

10

39

1.11

0.32-3.85

24-38.5 (30.2)

14

44

4.20

0.99-17.8

 38.5 (40.7)

15

45

5.16

1.27-21.0

Overall treatment

Cases

Controls

OR†

95%CI

RT only

30

68

1.0

Ref

RT+CT

18

104

0.45

0.22-0.91

* P trend <0.001; † adjusted for RT dose ovary and CT

• Highest risks in youngest patients • Induction period: 10-15 years

van Leeuwen JNCI 2003: 95;971