Haematology 2018

Cardiac constraints

• Mean heart dose is the parameter most often used

• Other parameters (V 5

, V 10

, V 20

, V 25

, V 30

, V 40

) are highly

correlated with mean heart dose

• The heart is evaluated as a single structure

• Very few data on toxicity according to where the high dose falls (e.g., cardiac valves, left ventricle)