Biophysical Society 59th Annual Meeting Program Guide

1709-P lat 8:30 am CROSSTALK BETWEEN RYR2 OXIDATION AND PHOSPHORYLATION CONTRIBUTES TO CARDIOMYOPATHY IN MICE WITH DUCHENNE MUSCULAR DYSTROPHY. George G. Rodney , Qiongling Wang, Guoliang Wang, Xander H.T. Wehrens 1710-P lat 8:45 am SECRETONEURIN, A NOVEL ENDOGENOUS CAMKII INHIBITOR, AUGMENTS CARDIOMYOCYTE CALCIUM HANDLING AND INHIBITS ARRHYTHMOGENIC CALCIUM RELEASE. Anett H. Ottesen, Cathrine R. Carlson, Andrew G. Edwards, Ole J. B. Landsverk, Rune F. Johansen, Morten K. Moe, Magnar Bjørås, Mats Stridsberg, Torbjørn Omland, Geir Christensen, Helge Røsjø, William E. Louch 1711-P lat 9:00 am LARGE-SCALE, AUTOMATED CALCIUM SPARK ANALYSIS USING ISPARK REVEALS FUNCTIONAL AND SPATIAL REMODELING DURING CARDIAC HYPERTROPHY. Qinghai Tian, Laura Schröder, Aline Flockerzi, Andre Zeug, Lars Kaestner, Peter Lipp 1712-P lat 9:15 am REGULATION OF CALCIUM CLOCK-MEDIATED PACEMAKING BY INOSITOL-1,4,5-TRISPHOSPHATE RECEPTORS IN MOUSE SINOATRIAL NODAL CELLS. Nidhi Kapoor , Andrew Tran, Jeanney Kang, Rui Zhang, Kenneth D. Philipson, Joshua I. Goldhaber 1713-P lat 9:30 am STRUCTURAL STUDIES OF IP3R BY CRYOEM. Qiu-Xing Jiang , Hui Zheng, Marc Llaguno 1714-P lat 9:45 am MULTIPLE CLOSED STATES OF THE RYANODINE RECEPTOR DETERMINED BY CRYOEM. Pablo Castro-Hartmann, Joshua Lobo, Montserrat Samso 1715-P lat 10:00 am CRYSTAL STRUCTURES OF THE RYANODINE RECEPTOR SPRY2 DOMAIN. Kelvin Lau , Filip Van Petegem

8:15 am –10:15 am , B allroom IV Platform Skeletal Muscle Mechanics, Structure, and Regulation Co-Chairs Brett Colson, University of Minnesota Barbara Joureau, VU University Medical Center, The Netherlands 1700-P lat 8:15 am ACTIVATION AND RELAXATION KINETICS IN SKELETAL AND CARDIAC MUSCLES. Srboljub M. Mijailovich , Boban Stojanovic, Djordje Nedic, Michael A. Geeves 1701-P lat 8:30 am ALTERNATIVE VERSIONS OF THE MYOSIN CONVERTER VARY CROSS-BRIDGE STIFFNESS AND MUSCLE FORCE GENERATION. Douglas M. Swank , Bernadette M. Glasheen, Seemanti Ramanath, Qian Wang 1702-P lat 8:45 am INTERMOLECULAR COOPERATIVITY OF SKELETAL MYOSINS ENHANCES FORCE OUTPUT IN MYOFILAMENTS. Motoshi Kaya , Yoshiaki Tani, Takumi Washio, Toshiaki Hisada, Hideo Higuchi 1703-P lat 9:00 am SHORTENING-INDUCED FORCE DEPRESSION IN SINGLE SARCOMERES IS ABOLISHED BY MGADP-ACTIVATION. Neal Trecarten , Fabio C. Minozzo, Felipe S. Leite, Dilson E. Rassier 1704-P lat 9:15 am FORCE-SARCOMERE LENGTH RELATIONS IN PATIENTS WITH THIN FILAMENT MYOPATHY CAUSED BY MUTATIONS IN NEB, ACTA1, TPM2, TPM3, KBTBD13, KLHL40 AND KLHL41. Barbara Joureau , J.M de Winter, Christopher T. Pappas, Edoardo Malfatti, Alan Beggs, Nigel Clarke, Norma Romero, Carol Gregorio, Henk Granzier, Ger J.M. Stienen, Coen C.A Ottenheijm 1705-P lat 9:30 am AN ACTIVE ROLE FOR THE Z-BAND DURING CONTRACTION AND RELAXATION. Lloyd Zhao, Lanette R. Fee, Sehyang Han, Michael K. Reedy, Robert J. Perz-Edwards 1706-P lat 9:45 am EFFECTS OF CARDIAC MYOSIN BINDING PROTEIN-C ON ACTIN MOTILITY ARE EXPLAINED WITH A DRAG- ACTIVATION-COMPETITION MODEL. SamWalcott , Steffen Docken, Samantha P. Harris 1707-P lat 10:00 am THE MYOSIN SUPER-RELAXED STATE IS REGULATED BY ESTRADIOL. Brett A. Colson , Karl J. Petersen, Brittany C. Collins, David D. Thomas, Dawn A. Lowe 8:15 am –10:15 am , R oom 307/308 Platform Intracellular Channels and Calcium Sparks and Waves Co-Chairs Montserrat Samso, Carnegie Mellon University Qiu-Xing Jiang, University of Texas Southwestern Medical Center 1708-P lat 8:15 am STRUCTURAL INSIGHTS INTO THE NATURE OF THE UNIQUE ANION BINDING SITE WITHIN THE CARDIAC RYANODINE RECEPTOR N-TERMINAL REGION AND ASSOCIATED DISEASE MUTATIONS. Siobhan Wong , Michele Bedin, Filip Van Petegem

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8:15 am –10:15 am , R oom 309/310 Platform Membrane Structure

Co-Chairs Stephanie Tristram-Nagle, Carnegie Mellon University Helgi Ingolfsson, Cornell University 1716-P lat 8:15 am

INTERACTION OF HIV-1 GAG PROTEIN’S MA MEMBRANE BINDING DOMAIN WITH MEMBRANE MIMICS PROBED BY LOW- AND WIDE-ANGLE X-RAY SCATTERING. Lauren O’Neil, Leah Langer, Davina Perera, Zachary Dell, John F. Nagle, Stephanie Tristram-Nagle 1717-P lat 8:30 am INFLUENCE OF DOMAIN SIZE ON STRUCTURE AND ELASTIC FLUCTUATIONS IN COMPLEX LIPID MIXTURES. Peter Heftberger , Benjamin Kollmitzer, Frederick Heberle, Jonathan Nickels, John Katsaras, Georg Pabst 1718-P lat 8:45 am PHASE COEXISTENCE IN LIPID MEMBRANES INDUCED BY BUFFERING AGENTS AND CHARGED LIPID HEADGROUPS. Merrell A. Johnson, Soenke Seifert, Millicent A. Firestone, Horia I. Petrache, Ann C. Kimble-Hill

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland