Biophysical Society 59th Annual Meeting Program Guide

to simplify and speed assay development. Executable protocols for high throughput experiments can be developed in minutes. Programming examples will show how operational actions have been optimized to decrease runtime and increase throughput. Streamlining data analysis of small or large data sets using our Q-Dat software will also be presented. Presenters

9:00 am –10:00 am , R oom 318 Subgroup Chairs Meeting 9:30 am –10:30 am , R oom 301/302/303 Career Center Workshop Successfully Navigating the International Job Search Applying for a job in one country while finishing up your education and training in another can be challenging, but it can be done with success. In this workshop we will discuss specific strategies to finding jobs in another country while one is abroad and how to leverage your networks in-country to access opportunities, especially those that are hidden. Special emphasis will be placed on establishing your reputation as a leader in your field with professionals in the country or region in which you wish to work. Case studies will be shared. 10:00 am –5:00 pm , H all C Biomolecular Discovery Dome Visit this 3-D portable Dome, sponsored by the Public Affairs Committee, to see how difficult biophysical topics can be made accessible to high school students and the public. Short videos that communicate the excitement of looking at macromolecular complexes and understanding the molecular basis for life are being shown throughout the week. 10:00 am –5:00 pm , H all C Exhibits 10:15 am –11:00 am , H all C Coffee Break 10:30 am –12:00 pm , H all C, R oom B Exhibitor Presentation SensiQ Technologies Inc High End Microscope Platform for Multimodal Live Cell Imaging SensiQ’s dynamic injection methods provide complete, one-pass kinetic and equilibrium data from a single injection while reducing statistical error/noise. Simply load one, highest analyte concentration vial and the instrument exposes the surface to either a stepwise (FastStep®) or continuous gradient (OneStep®) of concentrations. These approaches increase the ease/throughput of SPR experiments and provide complete data sets for interactions that are complicated by incomplete surface regeneration. FastStep® uses a patented onboard micro-mixing technique to create increasing fixed concentrations of analyte in real time without generating partial dissociation responses as the instrument prepares subsequent concentrations. This technique improves throughput by decreasing the time to complete a full run while simplifying data analysis. OneStep® is the ultimate evolution of FastStep®. Taylor dispersion fluidics establish a continuous gradient of analyte concentrations which is flowed over the surface to generate a sigmoidal binding curve. This technique introduces a time dependent variable that is not possible in traditional injection techniques and allows for the quantitative separation of multiple binding sites with different affinities. OneStep® also increases the dynamic range of allowable concentrations thereby removing the need to perform test injections or accurately guess the affinity of an unknown interaction. Importantly, OneStep® also provides added data content in SPR experiments by providing a measure of the analyte diffusion coefficient to help identify analytes that have a tendency to oligomerize or aggregate. SensiQs’ operational software was developed to simplify assay development and instrument operation. Using a drag and drop icon based programming approach, traditional program “scripting” is eliminated

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Derek Beahm, SensiQ Application Scientist Rick Cope, SensiQ Sales Representative

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10:45 am –12:45 pm , B allroom I Symposium Awards Symposium

Chair Dorothy Beckett, University of Maryland, Society President N o A bstract 10:45 am RECENT PROGRESS ON OLD PROBLEMS. Harold Scheraga N o A bstract 11:05 am MEMBRANE PROTEINS NEED LIPIDS. Anthony Watts N o A bstract 11:25 am EVOLUTION AND ASSEMBLY OF PROTEIN COMPLEXES. Sarah Teichmann N o A bstract 11:45 am SURPRISES I FOUND IN STUDYING MEMBRANES. Gerald W. Feigenson N o A bstract 12:05 pm TALES OF TUBULIN TAILS. Antonina Roll-Mecak N o A bstract 1:25 pm FROM CYTOKINESIS TO THE EARLY MOUSE EMBRYO DEVELOPMENT: A SIMPLE PHYSICAL VIEW OF CELL MORPHOGENESIS. Hervé Turlier Co-Chairs Dominika Gruszka, Cambridge University, United Kingdom Nathaniel Nucci, Rowan University 1740-P lat 10:45 am THE FOLDING OF SASG: A LONG AND REMARKABLY STRONG MONOMERIC PROTEIN RESPONSIBLE FOR BIOFILM FORMATION IS A HIGHLY COOPERATIVE SYSTEM. Dominika T. Gruszka , Fiona Whelan, Emanuele Paci, David J. Brockwell, Jennifer R. Potts, Jane Clarke 1741-P lat 11:00 am PUTTING ON THE SQUEEZE: SOLUTION NMR INVESTIGATIONS OF PROTEIN STRUCTURE AND HYDRATION UNDER HIGH PRESSURE. Nathaniel V. Nucci , Brian Fuglestad, Connie Liao, Evangelia A. Athanasoula, A. Joshua Wand 1742-P lat 11:15 am EFFECTS OF CROWDING, OSMOLYTES, TEMPERATURE AND PRESSURE ON THE INTERACTION POTENTIAL OF DENSE PROTEIN SOLUTIONS. Roland Winter 1743-P lat 11:30 am A MULTISCALE MODEL FOR PH-DEPENDENT FOLDING AND BINDING OF A CONDITIONALLY DISORDERED CHAPERONE. Logan S. Ahlstrom , Sean M. Law, Alex Dickson, Charles L. Brooks III 10:45 am –12:45 pm , B allroom II Platform Protein Fold Stability

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland

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