Biophysical Society 59th Annual Meeting Program Guide

1754-P lat

12:15 pm

1744-P lat 11:45 am STRUCTURAL ORIGIN OF LANDSCAPE ROUGHNESS IN PROTEIN FOLDING FROM SINGLE-MOLECULE FRET AND ALL-ATOM MOLECULAR DYNAMICS SIMULATIONS. Hoi Sung Chung , Stefano Piana-Agostinetti, David E. Shaw, William A. Eaton 1745-P lat 12:00 pm RESOLVING COOPERATIVE INTERACTIONS IN PROTEIN FOLDING. Jacob D. Marold , Thuy P. Dao, Tural Aksel, Doug Barrick 1746-P lat 12:15 pm MAPPING THE MECHANISM OF FAST PROTEIN FOLDING WITH MULTIPLE PROBES. Taras V. Pogorelov , Maxim B. Prigozhin, Shu-Han Chao, Martin Gruebele 1747-P lat 12:30 pm PHOTOBLEACHING AND STABILITY OF RED FLUORESCENT PROTEINS. Mengyang Xu , Deepu K. George, Ralph Jimenez, Andrea G. Markelz Co-Chairs Jianmin Cui, Washington University in St. Louis Kelly Aromolaran, Albert Einstein College of Medicine 1748-P lat 10:45 am EMERGING ROLE FOR KCNQ1 IN ISCHEMIA-INDUCED NEURONAL DEATH. Kelly A. Aromolaran , Jee-Yeon Hwang, Thomas V. McDonald, R.Suzanne Zukin 1749-P lat 11:00 am SPECTROSCOPIC AND BIOCHEMICAL STUDIES OF TRIP8B REGULATION OF HCN CHANNELS. John R. Bankston , Hannah A. DeBerg, Joel C. Rosenbaum, Peter S. Brzovic, Stefan Stoll, William N. Zagotta 1750-P lat 11:15 am EPILEPSY RELATED SLACK CHANNEL MUTANTS LEAD TO CHANNEL OVER-ACTIVITY BY TWO DIFFERENT MECHANISMS. Qiong-Yao Tang, Fei-Fei Zhang, Jie Xu, Ran Wang, Jian Chen, Zhe Zhang 1751-P lat 11:30 am QUANTUM CALCULATIONS SHOW A WATER COLUMN IN A POTASSIUM ION CHANNEL PORE, AND ITS ROLE IN GATING AND CONDUCTION. Alisher M. Kariev, Michael E. Green 1752-P lat 11:45 am PIP2 AND SURFACE EXPRESSION UNDERLIE APO- CALMODULIN DEPENDENT KV7.2/KCNQ2 CURRENT POTENTIATION. Carolina Gomis-Perez , Maria Virginia Soldovieri, Araitz Alberdi, Paolo Ambrosino, Michela Di Maria, Alessandro Alaimo, Ganeko Bernardo-Seisdedos, Covadonga Malo, Pilar Areso, Maurizio Taglialatela, Alvaro Villarroel 1753-P lat 12:00 pm THE MECHANISM OF KCNE1 MODULATION OF KCNQ1 CHANNELS. Mark A. Zaydman, Marina Kasimova, Kelli Delaloye, Jingyi Shi, Hongwu Liang, Zachary Beller, Mounir Tarek, Jianmin Cui 10:45 am –12:45 pm , B allroom III Platform Voltage-gated K Channels II

international travel awardee

DISRUPTION OF ASSEMBLY/CALMODULIN-BINDING COUPLING AND CALMODULIN-DEPENDENT POTENTIATION OF KV7.2 CHANNELS BY A EPILEPTOGENIC HELIX D MUTATION. Araitz Alberdi , Ganeko Bernardo-Seisdedos, Carolina Gomis-Perez, Alessandro Alaimo, Covadonga Malo, Elisabeth Butz, Christian Wahl-Schott, Pilar Areso, Alvaro Villarroel 1755-P lat 12:30 pm STATIN INHIBITS IKS INTERNALIZATION IN RESPONSE TO PROLONGED STRESS STIMULUS. Xiaorong Xu Parks , Elsa Ronzier, Rachael E. Abraham, Jin O-Uchi, Coeli M. Lopes

10:45 am –12:45 pm , B allroom IV Platform Membrane Receptors and Signal Transduction

Co-Chairs Kalina Hristova, Johns Hopkins University Nils Berglund, Bioinformatics Institute, Singapore 1756-P lat 10:45 am

CONFRONTATIONAL DYNAMICS OF A GPCR REVEALED BY SINGLE MOLECULE FRET. Reza Vafabakhsh , Joshua Levitz, Ehud Y. Isacoff 1757-P lat 11:00 am BIASED AGONISM AT OPIOID RECEPTORS: INSIGHTS FROM ANALYSIS OF STRUCTURAL INTERACTION FINGERPRINTS. Davide Provasi , Paola Bisignano, Marta Filizola 1758-P lat 11:15 am CONFORMATIONAL DYNAMICS OF A G PROTEIN-COUPLED RECEPTOR AT THE SINGLE-MOLECULE LEVEL. Rajan Lamichhane , Jeffrey J. Liu, Raymond C. Stevens, David P. Millar 1759-P lat 11:30 am ENTRY FROM THE LIPID BILAYER: A NOVEL PATHWAY FOR INHIBITION OF A PEPTIDE G-PROTEIN COUPLED RECEPTOR BY A LIPOPHILIC SMALL MOLECULE. Michael P. Bokoch , Hyunil I. Jo, James R. Valcourt, Yoga Srinivasan, Kazuma Yasuhara, Albert C. Pan, Ron O. Dror, David E. Shaw, William F. DeGrado, Shaun R. Coughlin 1760-P lat 11:45 am SINGLE MOLECULE IMAGING OF M 2 MUSCARINIC RECEPTORS IN LIVE HEART EXPLANTS. Gregory I. Mashanov , Tatiana A. Nenasheva, Ross A. Breckenridge, Nigel J.M. Birdsall, Justin E. Molloy 1761-P lat 12:00 pm THE STRUCTURAL BASIS FOR LIPID A RECOGNITION IN THE CD14 INNATE IMMUNE CO-RECEPTOR. Nils A. Berglund , Daniel A. Holdbrook, Syma Khalid, Peter J. Bond 1762-P lat 12:15 pm INSIDE-OUT SIGNALING OF ONCOGENIC EGFR MUTANTS PROMOTES LIGAND-INDEPENDENT DIMERIZATION. Christopher C. Valley , Donna J. Arndt-Jovin, Thomas M. Jovin, Mara P. Steinkamp, Alexey I. Chizhik, Narain Karedla, William S. Hlavacek, Bridget S. Wilson, Keith A. Lidke, Diane S. Lidke 1763-P lat 12:30 pm MECHANISMS OF AUTOINHIBITION AND DIMERIZATION OF THE EGF RECEPTOR FAMILY. Patrick Byrne , Kalina Hristova, Daniel Leahy

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland