Biophysical Society 59th Annual Meeting Program Guide

2233-P os B oard B370 COMPUTATIONAL MODEL OF CROSS-BRIDGE CYCLING AND FORCE GENERATION TO EXPLAIN THE EFFECT OF METABOLITES ON CARDIAC MUSCLE MECHANICS. Shivendra Tewari , Scott Bugenhagen, Bradley Palmer, Daniel Beard 2234-P os B oard B371 FROM CONTRACTILE NON-UNIFORMITIES AND MECHANICAL INSTABILITIES TO HYPERTROPHIC CARDIOMYOPATHY. Alf Mansson 2235-P os B oard B372 OXIDATIVE STRESS REGULATES TITIN ELASTICITY BY AFFECTING IG-DOMAIN STABILITY. Nazha Hamdani , Jorge Alegre-Cebollada, Martin Breitkreuz, Lars Leichert, Julio M. Fernandez, Wolfgang A Linke 2236-P os B oard B373 AB-CRYSTALLIN BINDS TO TITIN IG DOMAINS AND INCREASES STIFFNESS OF SKINNED CARDIAC TRABECULAE. Cameron W. Turtle , Georg Hochberg, Henrik Müller, Katja Gehmlich, Andrew Baldwin, Charles Redwood, Justin Benesch 2237-P os B oard B374 STRUCTURAL THERMODYNAMICS AND KINETICS OF THE CARDIAC MYOSIN/OMECAMTIV MECARBIL COMPLEX REVEALED BY TIME-RESOLVED FRET. John Rohde , Daniel O. Johnsrud, Sinziana Cornea, Kurt C. Peterson, Gregory D. Gillispie, David D. Thomas, Joseph M. Muretta 2238-P os B oard B375 IMPACT OF OMECAMTIV MECARBIL ON HUMAN β -CARDIAC MYOSIN STRUCTURE AND FUNCTION. Anja M. Swenson , Howard D. White, Christopher M. Yengo 2239-P os B oard B376 THE R146N AND R249Q MYOSIN MUTATIONS DISRUPT MOTOR FUNCTION AND MYOFIBRILLAR STRUCTURE AND CAUSE CARDIOMYOPATHY IN DROSOPHILA. Meera Cozhimuttam Viswanathan , William Kronert, Girish Melkani, Anju Melkani, Anthony Cammarato, Sanford Bernstein 2240-P os B oard B377 EFFECTS OF HYPERTROPHIC CARDIOMYOPATHY CAUSING R403Q MUTATION ON HUMAN BETA-CARDIAC MYOSIN BIOMECHANICAL FUNCTION: SINGLE MOLECULE TO ENSEMBLE STUDIES. Suman Nag , Ruth Sommese, Shirley Sutton, Kathleen Ruppel, James Spudich 2241-P os B oard B378 CHARACTERIZATION OF α -TROPOMYOSIN (TM) MUTANTS THAT CAUSE HYPERTROPHIC CARDIOMYOPATHY (HCM) IN HUMANS: IN VITRO MOTILITY ASSAYS WITH A MICROSCOPIC HEAT PULSE. Shuya Ishii , Kotaro Oyama, Madoka Suzuki, Masataka Kawai, Shin’ichi Ishiwata 2242-P os B oard B379 PEPTIDE MODULATION OF MYOSIN COILED COIL STABILITY MONITORED WITH OPTICAL AND FORCE SPECTROSCOPY. James W. Dunn , Michael Bih, Rohit Singh, Douglas D. Root 2243-P os B oard B380 ENHANCED TROPONIN-I BINDING EXPLAINS THE FUNCTIONAL CHANGES PRODUCED BY THE HYPERTROPHIC CARDIOMYOPATHY A8V MUTATION OF CARDIAC TROPONIN-C. Clara A. Michell , Jose R. Pinto, Javier E. Hasbun, Henry G. Zot

2221-P os B oard B358 EFFECTS OF THE CONNEXIN43 CT ON GAP JUNCTION SUB-DOMAIN ORGANIZATION AND MYOCYTE-FIBROBLAST INTERACTIONS IN THE INJURY BORDER ZONE. Emily L. Ongstad , Robert G. Gourdie 2222-P os B oard B359 MOLECULAR DYNAMICS OF SELECTIVE SUGAR PERMEATION THROUGH THE CONNEXIN26 CHANNEL. Lyna Luo, Angelo R. Rossi, Andrew L. Harris 2223-P os B oard B360 THE RESIDUES IN THE FIRST EXTRACELLULAR DOMAIN PLAY AN IMPORTANT ROLE IN TRANSJUNCTIONAL- VOLTAGE DEPENDENT GATING AND UNITARY CHANNEL CONDUCTANCE OF CX50 GAP JUNCTION CHANNELS. Xiaoling Tong, Hiroshi Aoyama, Swathy Sudhakar, Honghong Chen, Donglin Bai 2224-P os B oard B361 RESIDUES INVOLVED IN CX26 HEMICHANNELS VOLTAGE DEPENDENT GATING. Bernardo I. Pinto , David Baez-Nieto, Amaury Pupo, Agustin Martinez, Ramon Latorre, Carlos Gonzalez 2225-P os B oard B362 UNDERSTANDING THE CONFORMATIONAL DYNAMICS OF THE PORIN OCCK5. Karunakar Reddy Pothula 2226-P os B oard B363 CYCLODEXTRIN INTERACTION WITH SPECIFIC CHANNEL CYMA FROM K. OXYTOCA. Satya Prathyusha Bhamidimarri , Jing Lu, Jigneshkumar Dahyabhai Prajapati, Ivan Barcena Uribarri, Bert van den Berg, Ulrich Kleinekathoefer, Mathias Winterhalter 2227-P os B oard B364 MIMICKING BIOLOGY WITH NANOMATERIALS: CARBON NANOTUBE PORINS IN LIPID MEMBRANES. Aleksandr Noy 2228-P os B oard B365 UNDERSTANDING THE TRANSLOCATION OF FLUOROQUINOLONES THROUGH OMPC USING THE METADYNAMICS. Jigneshkumar D. Prajapati , Harsha Bajaj, Matteo Ceccarelli, Mathias Winterhalter, Ulrich Kleinekathöfer 2229-P os B oard B366 SINGLE-MOLECULE DETECTION OF INSERTION AND FOLDING OF OMPA IN DROPLET INTERFACE BILAYERS. Eve E. Weatherill , David P. Marshall, Mark I. Wallace Cardiac Muscle Mechanics and Structure II (Boards B367-B386) 2230-P os B oard B367 FROM MOLECULE TO ORGAN: A MULTISCALE SIMULATOR OF HEART CONTRACTION. Lorenzo Marcucci , Toshio Yanagida, Takumi Washio 2231-P os B oard B368 SUBSTRATE STIFFNESS-MODULATED REGISTRY PHASE CORRELATIONS IN CARDIOMYOCYTES MAPS STRUCTURAL ORDER TO COHERENT BEATING. Kinjal Dasbiswas , Stephanie J. Majkut, Dennis E. Discher, Samuel A. Safran 2232-P os B oard B369 international travel awardee REGULATION OF CARDIOMYOCYTE T-TUBULE ORGANIZATION AND DENSITY BY VENTRICULAR WALL STRESS. Marianne Ruud , Michael Frisk, Per Andreas Norseng, Åsmund Treu Røe, Emil Espe, Jan Magnus Aronsen, Ivar Sjaastad, Ole M. Sejersted, Geir Arve Christensen, William Edward Louch

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland