Biophysical Society 59th Annual Meeting Program Guide

2244-P os B oard B381 STEADY-STATE PREDICTIONS FROM A COMPACT COOPERATIVE KINETIC MODEL OF CARDIAC SARCOMERE DYNAMICS. William C. Hunter 2245-P os B oard B382 SERINE 61 PHOSPHORYLATION RESCUES CARDIOMYOPATHIC EFFECTS OF TROPOMYOSIN MUTATION. Gerrie P. Farman, Marek Orzechowski, Stefan Fischer, Lehman William, Jeffrey R. Moore 2246-P os B oard B383 MOLECULAR DYNAMICS STUDIES ON PHOSPHORYLATED AND UNPHOSPHORYLATED CARDIAC TROPONIN. Andrew E. Messer , Maria Papadaki, Steven B. Marston, Ian R. Gould 2247-P os B oard B384 BORROWING FROM THE PLATYPUS: PROLINE SUBSTITUTION IN CARDIAC TROPONIN I. Anthony D. Vetter , Brian R. Thompson, Evelyne H. Houang, Yuk Sham, Joseph M. Metzger 2248-P os B oard B385 A COARSE-GRAINED MODEL TO STUDY CALCIUM ACTIVATION OF THE CARDIAC THIN FILAMENT. Jing Zhang , Steven D. Schwartz 2249-P os B oard B386 AN EXPLICITLY SOLVATED FULL ATOMISTIC MODEL OF THE CARDIAC THIN FILAMENT AND APPLICATION ON THE CALCIUM BINDING AFFINITY EFFECTS FROM FAMILIAL HYPERTROPHIC CARDIOMYOPATHY LINKED MUTATIONS. Michael R. Williams , Sarah J. Lehman, Jil C. Tardiff, Steven D. Schwartz Microtubules, Structure Dynamics, and Associated Proteins (Boards B387-B405) 2250-P os B oard B387 TRANSFORMATION OF TAXOL-STABILIZED MICROTUBULES INTO INVERTED TUBULIN TUBULES TRIGGERED BY A TUBULIN CONFORMATION SWITCH. Chaeyeon Song , Miguel A. Ojeda-Lopez, Daniel J. Needleman, Avi Ginsburg, Phillip A. Kohl, Youli Li, Herbert P. Miller, Leslie Wilson, Uri Raviv, Myung Chul Choi, Cyrus R. Safinya 2251-P os B oard B388 SINGLE-MOLECULE FRET REVEALS AN EXTENDED STRUCTURE OF TAU BOUND TO TUBULIN HETERODIMERS. Ana M. Melo , Garrett Cobb, Juliana Coraor, Shana Elbaum-Garfinkle, Elizabeth Rhoades 2252-P os B oard B389 STATISTICAL MECHANICS PROVIDES NOVEL INSIGHTS INTO MICROTUBULE STABILITY AND MECHANISM OF SHRINKAGE. Ishutesh Jain , Mandar M. Inamdar, Ranjith Padinhateeri 2253-P os B oard B390 MOLECULAR DYNAMICS STUDY OF THE EFFECT OF POLYAMINE ON MICROTUBULE CONFORMATIONS. Chola Regmi , Shengfeng Cheng 2254-P os B oard B391 MOLECULAR BASIS FOR AGE-DEPENDENT MICROTUBULE ACETYLATION. Antonina Roll-Mecak , Agnieszka Szyk, Alexandra Deaconescu, Jeffrey Spector, Max Valenstein, Niko Grigorieff 2255-P os B oard B392 KATANIN ACTIVITY IS REGULATED BY COMMON CELLULAR COMPONENTS. Megan E. Bailey , Jennifer L. Ross

2256-P os B oard B393 MOLECULAR BASIS FOR AGE-DEPENDENT ACETYLATION BY TUBULIN ACETYLTRANSFERASE. Jeffrey Spector , Agnieszka Szyk, Alexandra M. Deaconescu, Max Valenstein, Benjamin Goodman, Vasilisa Kormendi, Nikolaus Grigorieff, Antonina Roll-Mecak 2257-P os B oard B394 international travel awardee MICROTUBULE ELECTRODYNAMICS ASSOCIATED WITH VIBRATIONAL NORMAL MODES. Michal Cifra , Daniel Havelka, Marco A. Deriu, Ondřej Kučera 2258-P os B oard B395 MICROTUBULE-DRIVEN CONFORMATIONAL CHANGES IN PLATELET MORPHOGENESIS. Wylie Stroberg , Seth Lichter 2259-P os B oard B396 TRIM50 INTERACTS WITH MICROTUBULES TO FACILITATE VESICLE TRAFFICKING IN GASTRIC PARIETAL CELLS. Kristyn N. Gumpper , Mingzhai Sun, Jiaqing Huang, Pei-Hui Lin, Miyuki Nishi, Hiroshi Takeshima, Jianjie Ma 2260-P os B oard B397 GENERATION OF DIFFERENTIALLY MODIFIED MICROTUBULES USING IN VITRO ENZYMATIC APPROACHES. Annapurna Vemu 2261-P os B oard B398 DYNAMICS OF MICROTUBULE NETWORKS WITH ANTIPARALLEL CROSSLINKERS. Kasimira T. Stanhope , Jennifer L. Ross 2262-P os B oard B399 KINETOCHORE DYNAMIC STRUCTURE AT SUPER- RESOLUTION ACCURACY AND MECHANICAL STIFFNESS REVEALED IN VITRO BY COMBINED TIRF AND OPTICAL TWEEZERS. Yi Deng , Kwaku Opoku, Charles Asbury 2263-P os B oard B400 ASYMMETRIC FRICTION OF NON-MOTOR MAPS CAN LEAD TO THEIR DIRECTIONAL MOTION IN ACTIVE MICROTUBULE NETWORKS. Scott Forth , Kuo-Chiang Hsia, Yuta Shimamoto, Tarun Kapoor 2264-P os B oard B401 THE DETERMINATION OF YOUNG’S MODULUS FOR MICROTUBULES STABILIZED WITH TAXOL AND ANALYSIS OF VIBRATIONAL MODES. John Palmieri , Camelia Prodan, Gordon Thomas 2265-P os B oard B402 REGULATION OF TAU DYNAMICS BY PHOSPHORYLATION IN THE SQUID GIANT AXON. Miranda Redmond , Gregory Hoeprich, Meghan Pantalia, Gerardo Morfini, Christopher Berger 2266-P os B oard B403 GENERATION OF DIFFERENTIALLY MODIFIED MICROTUBULES USING IN VITRO ENZYMATIC APPROACHES. Annapurna Vemu, Christopher P. Garnham , Duck- Yeon Lee, Antonina Roll-Mecak 2267-P os B oard B404 A COMPARISON OF THE CONFORMATIONAL CHANGES OF TAU ISOFORMS IN THE TAU-TUBULIN COMPLEX. Juliana Coraor , Ana M. Melo, Garrett Cobb, Elizabeth Rhoades 2268-P os B oard B405

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ANALYZING THE FREQUENCY OF THERMALLY FLUCTUATING SEGMENTS OF MICROTUBULES. Jennifer Rochette , Camelia Prodan, Gordon Thomas

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland