Biophysical Society 59th Annual Meeting Program Guide

101-P lat 8:30 am WHY ARE KINESIN-2 KIF3AB AND KIF3AC SO PROCESSIVE? Stephanie Guzik-Lendrum , Katherine C. Rank, Brandon Bensel, Ivan Rayment, Susan P. Gilbert 102-P lat 8:45 am SRC KINASE PHOSPHO-REGULATION OF THE HUMAN MITOTIC KINESIN EG5. Sarah Rice , Kathleen M. Gifford, Joshua S. Waitzman, Taylor Poor, Barbara Mann, Patricia Wadsworth 103-P lat 9:00 am EMERGENCE OF LARGE-SCALE VORTICES OF MICROTUBULES COLLECTIVELY DRIVEN BY AXONEMAL DYNEINS. Naoki Kanatani, Kazuhiro Oiwa 104-P lat 9:15 am ULTRASTRUCTURE OF DYNACTIN COMPLEX: A MEDIATOR OF CYTOPLASMIC DYNEIN. Saikat Chowdhury , Stephanie A. Ketcham, Trina A. Schroer, Gabriel C. Lander 105-P lat 9:30 am A MECHANICAL SWITCH FROM DIFFUSION TO DIRECTIONAL MOTION ACTIVATES ATPASE IN DYNEIN MOTOR. Seiichi Uchimura, Takashi Fujii, Hiroko Takazaki, Rie Ayukawa, Yosuke Nishikawa, Itsushi Minoura, You Hachikubo, Genji Kurisu, Kazuo Sutoh, Takahide Kon, Keiichi Namba, Etsuko Muto 106-P lat 9:45 am CYTOPLASMIC DYNEIN RING TILTING DETECTED BY COMBINED POLTIRF AND SUB-PIXEL PARTICLE TRACKING OF SEMICONDUCTOR QUANTUM RODS. Lisa G. Lippert , Tali Dadosh, Benjamin T. Diroll, Jeffrey T. Hallock, Christopher B. Murray, Erika LF Holzbaur, Samara L. Reck-Peterson, Yale E. Goldman 107-P lat 10:00 am BIDIRECTIONAL HELICAL MOTILITY OF CYTOPLASMIC DYNEIN AROUND MICROTUBULES. Sinan Can , Mark DeWitt, Ahmet Yildiz 8:30 am –10:30 am , R oom 333 Minority Affairs Committee Meeting 9:00 am –10:00 am , R oom 301/302/303 Career Center Workshop Selling Yourself to the Life Sciences Industry The industrial employer is looking for a different set of skills and attitudes than either the academic or government employer. Learn what the pharmaceutical/biotechnology industries want to hear from potential employees and why. Learn how to develop and best position your marketing message in order to improve the chances of a successful industrial job search. 10:00 am –5:00 pm , H all C Biomolecular Discovery Dome Visit this 3-D portable Dome, sponsored by the Public Affairs Committee, to see how difficult biophysical topics can be made accessible to high school students and the public. Short videos that communicate the excitement of looking at macromolecular complexes and understanding the molecular basis for life are being shown throughout the week. 10:00 am –5:00 pm , H all C Exhibits 10:15 am –11:00 am , H all C Coffee Break

10:30 am –11:30 am , R oom 301/302/303 Career Center Workshop Career Planning and Job Searching for

F R I D A Y

S A T U R D A Y U N D A Y

Science Professionals: Academic Opportunities

Learn how to create a flexible career plan for yourself, and identify and leverage your skills, expertise and experience to find a career (not just a job) that is right for you. Special emphasis will be placed on tips for finding and launching a career in academia, but we will also incorporate the development of a contingency plan for the unexpected twists and turns in life. 10:30 am –12:00 pm , H all C, R oom B Exhibitor Presentation Carl Zeiss Microscopy Technology Innovations from ZEISS, the New ZEISS LSM 880 Confocal with Airyscan and the ZEISS Lightsheet Z.1 New microscopes from ZEISS address both ends of the spectrum of samples, live high speed imaging with superresolution and high speed imaging of large live and fixed tissues. Learn how the ZEISS LSM 880 with Airyscan maintains the mantra that each photon of emission light is precious, while expanding the triangle of sensitivity, resolution and speed of acquisition. The LSM 880 with Airyscan allows you to use multicolor samples with any label and get image quality like you’ve never seen before. With Airyscan you are always able to select the optimal acquisition strategy for your sample: Simply decide whether you want to gain 1.7x higher resolution in all three dimensions – resulting in a 5x smaller confocal volume. Or push the sensitivity beyond the limits of all conventional confocals. Or use the increase in signal-to-noise ratio to speed up your image acquisition. Traditionally, deeply imaging into intact tissue typically requires multiphoton excitation to penetrate deeper than near the surface of a tissue. Using a “clearing” method to remove the light obstructing opaque molecules from a tissue has been another technique for deep imaging. Techniques such as SCALE, CLARITY, ClearT, SeeDB, CUBIC and others have allowed researchers to image deeper than a millimeter into cleared animal model brains and organs. The ZEISS Lightsheet Z.1 features high speed image acquisition and greatly reduced photodamage making imaging of live developmental samples and fixed and cleared tissues easier than ever before. Come learn about using the innovative ZEISS Lightsheet Z.1 microscope for imaging of fixed and cleared tissues. Presenters Joseph Huff, Product Marking Manager, Laser Scanning and Superresolution Microscopy, Carl Zeiss Microscopy LLC Scott Olenych, Product Marketing Manager, Imaging Products, Carl Zeiss Microscopy LLC 10:30 am –12:30 pm , R oom 313 International Relations Committee Meeting

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland