Biophysical Society 59th Annual Meeting Program Guide

2541-P lat 1:30 pm SERCA LOCATED IN THE JUNCTIONAL SR SHAPES CALCIUM RELEASE IN CARDIAC MYOCYTES. Terje R. Kolstad , Mathis K. Stokke, Espen Stang, Sverre H. Brorson, Louch E. William, Ole M. Sejersted 2542-P lat 1:45 pm LARGE AMPLITUDE RATE-DEPENDENT MECHANICAL ALTERNANS MAY PRECEDE ARRHYTHMOGENESIS IN HUMAN HEART FAILURE AND ARE LINKED TO ELECTRICAL ALTERNANS VIA ABNORMAL CALCIUM HANDLING. Melanie Zile , Natalia Trayanova 2543-P lat 2:00 pm NA + /H + EXCHANGE BLOCKERS REVEAL THE EXISTENCE OF A SKELETAL MUSCLE CA 2+ /H + EXCHANGER, WHICH IS ALTERED IN MALIGNANT HYPERTHERMIA MUSCLE CELLS. Gaelle Robin , Francisco Altamirano, Eric Esteve, Isaac N. Pessah, Paul D. Allen, Jose R. Lopez 2544-P lat 2:15 pm CALCIUM SPARKLETS IN INTACT MAMMALIAN SKELETAL MUSCLE FIBERS EXPRESSING THE EMBRYONIC CAV1.1 SPLICE VARIANT. Beatrix Dienes, Nasreen Sultana, Janos Vincze, Monika Sztretye, Peter Szentesi, Bernhard E. Flucher, Laszlo Csernoch 2545-P lat 2:30 pm CALCIUM CHANNEL DYSFUNCTION IN A MUTANT MOUSE MODEL OF MALIGNANT HYPERTHERMIA(CAV1.1 R174W). Donald Beqollari, Christin F. Romberg, Wei Feng, Jose R. Lopez, Manuela Lavorato, Stefano Perni, Philip M. Hopkins, Clara Franzini- Armstrong, Isaac N. Pessah, Paul D. Allen, Kurt G. Beam, Roger A. Bannister 2546-P lat 2:45 pm SPATIALLY LOCALIZED DISRUPTIONS OF VOLTAGE ACTIVATED CALCIUM RELEASE IN MTM1-DEFICIENT MUSCLE FIBERS. Candice Kutchukian, Karine Poulard, Anna Buj- Bello, Vincent Jacquemond Co-Chairs Camilo Andres Aponte-Santamaria, Heidelberg Institute for Theoretical Studies (HITS), Germany Anthony Peng, Stanford University 2547-P lat 1:00 pm THE PRIMARY CILIUM IS A SELF-ADAPTABLE, INTEGRATING NEXUS FOR MECHANICAL STIMULI AND CELL SIGNALING. An M. Nguyen, Yuan N. Young, Christopher R. Jacobs 2548-P lat 1:15 pm MECHANOSENSITIVE VON WILLEBRAND FACTOR PROTEIN- PROTEIN INTERACTIONS REGULATE HEMOSTASIS. Camilo A. Aponte Santamaría , Volker Huck, Sandra Posch, Agnieszka K. Bronowska, Sandra Grässle, Maria A. Brehm, Tobias Obser, Reinhard Schneppenheim, Peter Hinterdorfer, Stefan W. Schneider, Carsten Baldauf, Frauke Gräter 2549-P lat 1:30 pm STRUCTURAL STUDY OF A NOVEL PARTIAL CALCIUM- FREE LINKER AND A POSITIVELY SELECTED VARIATION IN PROTOCADHERIN-15: IMPLICATIONS FOR HEARING AND CELL ADHESION. Robert E. Powers , Rachelle Gaudet, Marcos Sotomayor 1:00 pm –3:00 pm , R oom 309/310 Platform Mechanosensation

2550-P lat 1:45 pm CALCIUM INFLUX THROUGH TRPV1 INHIBITS PIEZO CHANNELS VIA PHOSPHOINOSITIDE DEPLETION. Istvan Borbiro , Doreen Badheka, Tibor Rohacs 2551-P lat 2:00 pm PIEZO1 TRANSDUCES EXTRACELLULAR MATRIX MECHANICAL CUES TO DIRECT HUMAN NEURAL STEM CELL FATE. Medha M. Pathak , Jamison L. Nourse, Truc Tran, Jennifer Hwe, Janahan Arulmoli, Dai Trang T. Le, Elena Bernardis, Lisa A. Flanagan, Francesco Tombola 2552-P lat 2:15 pm MECHANOSIGNALLING OF FOCAL ADHESION KINASE. Jing Zhou , Camilo Aponte-Santamaria, Agnieszka Bronowska, Frauke Gräter 2553-P lat 2:30 pm MODULATION OF RAT AUDITORY HAIR CELL MECHANOTRANSDUCTION CHANNEL RESTING OPEN PROBABILITY IMPLICATES A ROLE FOR THE LIPID BILAYER. Anthony Peng , Radhakrishnan Gnanasamdandam, Frederick Sachs, Anthony Ricci 2554-P lat 2:45 pm PROBING THE STRUCTURE AND FUNCTION OF TMC1 IN SENSORY HAIR CELLS USING MUTAGENESIS AND CYSTEINE MODIFICATION. Xiao-Ping Liu , Bifeng Pan, Yukako Asai, Kyoto Kurima, Andrew J. Griffith, Jeffrey R. Holt international travel awardee INITIATION OF ASYMMETRIC ROLLING-CIRCLE PLASMID REPLICATION BY REPD STUDIED USING MAGNETIC TWEEZERS. Algirdas Toleikis , Simone Kunzelmann, Gregory I. Mashanov, Martin R. Webb, Justin E. Molloy 2556-P lat 1:15 pm MECHANISTIC STUDIES OF DNA-PROTEIN INTERACTIONS IN BACTERIOPHAGE T4 DNA REPLICATION COMPLEXES AT SINGLE-BASE RESOLUTION. Davis Jose , Lee Wonbae, Gillies P. John, Marcus H. Andrew, Peter H. von Hippel 2557-P lat 1:30 pm DNA TRANSLOCATIONS IN REAL-TIME: INSIGHTS INTO NON-HOMOLOGOUS END JOINING PATHWAY. Andrea Candelli , Ineke Brouwer, Gerrit Sitters, Stephanie Heerema, Mauro Modesti, Erwin J.G. Peterman, Gijs J.L. Wuite 2558-P lat 1:45 pm CORRELATIVE NANOMANIPULATION AND COLOCALIZATION OF SINGLE-MOLECULES TO STUDY TRANSCRIPTION-COUPLED DNA REPAIR. Evan T. Graves , Camille Duboc, Jun Fan, Terence Strick 2559-P lat 2:00 pm FUNCTIONAL IMPLICATIONS OF THE RECQ HELICASE - TOPOISOMERASE III - SSB COMPLEX: INSIGHTS FROM SINGLE MOLECULE MEASUREMENTS. Maria Mills , Yeonee Seol, Keir Neuman 1:00 pm –3:00 pm , R oom 314/315 Platform DNA Replication and Transcription Co-Chairs Enrico Gratton, University of California, Irvine Laura Finzi, Emory University 2555-P lat 1:00 pm

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland