Biophysical Society 59th Annual Meeting Program Guide

2898-P os B oard B328 SUPERRESOLUTION MICROSCOPY REVEALS SODIUM CHANNEL LOCALIZATION WITHIN INTERCALATED DISK MICRODOMAINS: IMPLICATIONS FOR EPHAPTIC COUPLING. Rengasayee Veeraraghavan , Joyce Lin, James P. Keener, Steven Poelzing, Robert G. Gourdie 2899-P os B oard B329 LOSS OF CALMODULIN-MEDIATED REGULATION OF NA + CHANNEL CAUSES REMODELING OF ELECTRICAL AND JUNCTIONAL PROTEINS; AND INDUCES DILATED CARDIOMYOPATHY IN IQ/AA +/- MICE. Rosy Joshi-Mukherjee , Hana Cho, Takeshi Aiba, Deborah DiSilvestre, Gordon F. Tomaselli 2900-P os B oard B330 MUTATION SPECIFIC DRUG RESPONSE AND CARDIAC RISK IN LONG QT TYPE 3. Elsa Ronzier , Yitschak Biton, Alessandra Matavel, Arthur Moss, Wojciech Zareba, Coeli Lopes 2901-P os B oard B331 ROTATIONAL SYMMETRY OF TWO PYRETHROID RECEPTOR SITES IN THE MOSQUITO SODIUM CHANNEL. Yuzhe Du, Yoshiko Nomura, Ke Dong, Boris S. Zhorov 2902-P os B oard B332 NAV1.7 INHIBITOR, PF-05089771, INHIBITS FAST- AND SLOW-INACTIVATED CHANNELS WITH SIMILAR AFFINITIES. Jonathan Theile , Matthew Fuller, Mark Chapman 2903-P os B oard B333 STRUCTURAL MODELING OF LOCAL ANESTHETIC BINDING TO THE PORE-DOMAIN OF HUMAN NAV1.5 IN OPEN AND CLOSED STATES USING ROSETTA. Kevin DeMarco 2904-P os B oard B334 UNDERSTANDING THE STATE DEPENDENCE OF VOLTAGE SENSOR TOXIN ACTION ON VOLTAGE GATED SODIUM CHANNELS. Phuong T. Nguyen , Ian H. Kimball, Kenneth S. Eum, Bruce E. Cohen, Jon T. Sack, Vladimir Yarov-Yarovoy 2905-P os B oard B335 TARGETING PROTEIN:PROTEIN INTERACTION SITES FOR DRUG DEVELOPMENT AGAINST VOLTAGE-GATED SODIUM CHANNELS. Syed R. Ali , Zhiqing Liu, Miroslav N. Nenov, Neli I. Panova-Elektro, Jia Zhou, Svetla Stoilova-McPhie, Fernanda Laezza 2906-P os B oard B336 SODIUM SELECTIVE CONDUCTION, INACTIVATION AND INHIBITION MECHANISMS USING THE BACTERIAL NAVAB CHANNEL. Céline Boiteux, Igor Vorobyov, Robert J. French, Christopher French, Vladimir Yarov-Yarovoy, Toby W. Allen 2907-P os B oard B337 MOLECULAR DYNAMICS SIMULATIONS DESCRIBE THE MECHANISM OF K BLOCK IN BACTERIAL NAV CHANNELS. Van Ngo, Yibo Wang, Sergei Noskov, Stephan Haas, Robert A. Farley 2908-P os B oard B338 MOLECULAR DYNAMICS STUDY OF ION CONDUCTION AND SELECTIVITY IN A PROKARYOTIC ION CHANNEL. Karen M. Callahan , Benoît Roux 2909-P os B oard B339 COUPLING OF CHANNEL FLUCTUATIONS IN ION PERMEATION AND SELECTIVITY IN BACTERIAL SODIUM CHANNEL NAVAB. Christopher Ing , Nilmadhab Chakrabarti, Ning Zheng, William A. Catterall, Régis Pomès

Nucleo-Cytoplasmic Transport (Boards B317-B322)

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2887-P os B oard B317 OBSERVING SIGNAL TRANSDUCTION DIRECTLY AT THE SINGLE-MOLECULE LEVEL IN LIVE EUKARYOTIC CELLS. Adam JMWollman , Sviatlana Shashkova, Erik Hedlund, Stefan Hohmann, Mark C. Leake 2888-P os B oard B318 IN VIVO ANALYSIS OF PROTEIN CROWDING IN THE NUCLEAR PORE COMPLEX DURING INTERPHASE AND MITOSIS. Hide A Konishi , Suguru Asai, Tomonobu M Watanabe, Shige H Yoshimura 2889-P os B oard B319 MICROINJECTION OF FL-TRNA FOR THE STUDY OF TRNA SUBCELLULAR DYNAMICS. Sean E. Anderson , Anna Kashina, Haim H. Bau, Barry S. Cooperman 2890-P os B oard B320 INVOLVEMENT OF WATER MOLECULES IN THE FORMATION OF HYDROPHOBIC BARRIER IN THE NUCLEAR PORE COMPLEX. Suguru Asai , Hide A. Konishi, Shige H. Yoshimura 2891-P os B oard B321 MONITORING AND MODELING EFFECTS OF IGF1, INSULIN AND GREEN TEA COMPOUND EGCG ON NUCLEAR- CYTOPLASMIC DISTRIBUTION OF FOXO1-GFP IN SKELETAL MUSCLE FIBERS. Robert Wimmer, Sarah Russell , Bradford Peercy, Martin Schneider 2892-P os B oard B322 THE AUTOPHAGOSOME MARKER LC3 UNDERGOES REGULATED TARGETING TO THE NUCLEUS AND NUCLEOLUS. Lewis J. Kraft , Jacob Dowler, Anne K. Kenworthy Voltage-gated Na Channels (Boards B323-B350) 2893-P os B oard B323 RESTING STATE OF S4 IDENTIFIED FOR EACH DOMAIN OF NAV1.2 USING OMEGA CURRENT TECHNIQUE. Claudia Lehmann , Hansjakob Heldstab, Nikolaus G. Greeff 2894-P os B oard B324 SELECTIVE IMMOBILIZATION OF S4 IN DOMAIN III AND IV OF RAT BRAIN NAV1.2 SHOWN BY OMEGA CURRENTS. Nikolaus Greeff , Hansjakob Heldstab, Claudia Lehmann 2895-P os B oard B325 VOLTAGE SENSOR DOMAINS AND CLOSED-STATE INACTIVATION IN SODIUM CHANNELS. James R. Groome 2896-P os B oard B326 GATING PORE CURRENTS ARE COMMON DEFECTS OF TWO NAV1.5 MUTATIONS IN PATIENTS WITH MIXED ARRHYTHMIAS AND DILATED CARDIOMYOPATHY. Adrien Moreau , Pascal Gosselin-Badaroudine, Lucie Delemotte, Michael L. Klein, Mohamed Chahine 2897-P os B oard B327 INTERACTION OF THE CARDIAC SODIUM CHANNEL ALPHA- SUBUNITS LEADS TO COUPLED GATING PROPERTIES. Jérôme Clatot , Haiyan Liu, Eckard Ficker, Isabelle Deschênes

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland