Biophysical Society 59th Annual Meeting Program Guide

2910-P os B oard B340 EXPRESSION, PURIFICATION, AND PRELIMINARY CHARACTERIZATION OF A HUMAN CARDIAC SODIUM CHANNEL VOLTAGE SENSING DOMAIN. Mohammed H. Bhuiyan , Sebastien F. Poget 2911-P os B oard B341 A THERMODYNAMIC ANALYSIS OF DISEASE-CAUSING MUTATIONS IN THE NAV1.5 C-TERMINUS. Ching-Chieh Tung, Ricardo E. Rivera-Acevedo, Bernd R. Gardill , Filip Van Petegem 2912-P os B oard B342 FUNCTIONAL CONSEQUENCES OF A NOVEL NAV1.9 MUTATION (L1302F) CAUSING CONGENITAL INSENSITIVITY TO PAIN. Carlos G. Vanoye , Tatiana V. Abranova, Chris C. Ramdoski, Paul Goldberg, Charles J. Cohen, Alfred L. George 2913-P os B oard B343 INFANT SUDDEN DEATH: NOVEL MUTATIONS RESPONSIBLE FOR IMPAIRED NAV1.5 CHANNEL FUNCTION. Jace Morganstein, Kundan Jana, Monique N. Foster, Tomoe Y. Nakamura, Thomas V. McDonald, Yingying Tang, William A. Coetzee 2914-P os B oard B344 BIOPHYSICAL AND MOLECULAR ANALYSIS OF THE SODIUM CURRENT IN HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES. Brian K. Panama, Robert J. Goodrow, Serge Sicouri, Charles Antzelevitch, Jacqueline A. Treat, Jonathan M. Cordeiro 2915-P os B oard B345 NAV1.5 C-TERMINAL DOMAINS INFLUENCE CALCIUM REGULATION OF FAST INACTIVATION SEPARATELY FROM CALMODULIN INTERACTION. Franck Potet , Svetlana Stepanovic, Sabina Kupershmidt, Alfred L. George, Jr 2916-P os B oard B346 CAMKII-DEPENDENT REGULATION OF CARDIAC SODIUM CHANNEL. Federica Farinelli , Deborah DiSilvestre, Peihong Dong, Yanli Tian, Gordon Tomaselli 2917-P os B oard B347 RECRUITMENT OF CALMODULIN TO THE TAIL OF THE VOLTAGE-GATED SODIUM CHANNEL NAV1.2. Liam Hovey , Corinne Andresen, Dagan Marx, Madeline Shea 2918-P os B oard B348 COUPLING COMPARTMENTAL MODELS TO LIVE NEURONS TO INVESTIGATE ACTION POTENTIAL MECHANISMS. Marco A. Navarro , Sarah L. Debs, Lorin S. Milescu 2919-P os B oard B349 OPTIMIZING A NAV1.5 MARKOV-MODEL WITH A GENETIC ALGORITHM. Zach R. Teed , Arie Krumholtz, Jonathon R. Silva 2920-P os B oard B350 RATE CONSTANT MODELS CANNOT DESCRIBE MOVEMENT OF CHARGED ATOMS OR MOLECULES. Bob Eisenberg Voltage-gated Ca Channels (Boards B351-B370) 2921-P os B oard B351 TARGETING T-TYPE CHANNELS WITH PROTXII-LIKE TOXINS. Autoosa Salari , Mirela Milescu

2922-P os B oard B352 ENGINEERING SELECTIVITY IN RGK PROTEIN INHIBITION OF CAV1/CAV2 CHANNELS. Akil Puckerin 2923-P os B oard B353 international travel awardee VENTRICULAR L-TYPE CA 2+ CHANNELS AND EXPRESSION OF RGK PROTEINS IN MOUSE MODELS ASSOCIATED WITH DIABETES. Jessica Köth , Christian Fabisch, Stefan Herzig, Jan Matthes 2924-P os B oard B354 INHIBITION OF HUMAN CA V 2.3 CHANNELS VIA μ-, δ - AND κ -OPIOID RECEPTOR ACTIVATION. Geza Berecki, Leonid Motin, David J. Adams 2925-P os B oard B355 CONTROL OF FUNCTIONAL TARGETING OF CAV1.2 CHANNELS BY THE Γ 6. Roman Shirokov , Thomas Comollo, Rose Rendon 2926-P os B oard B356 L-TYPE CA 2+ CHANNEL CAVB SUBUNITS ASSOCIATE WITH AND DIFFERENTIALLY REGULATE THE CARDIAC CAV3.2 T-TYPE CA 2+ CHANNEL CURRENTS. Marites T. Woon , Ravi C. Balijepalli 2927-P os B oard B357 HOMOLOGOUS SERINE/THREONINE IN THE CA V 2.2 α 1 AND 2.3 α 1 SUBUNITS BEHAVE SIMILARLY, AS STIMULATORY AND INHIBITORY PKC SITES. Ganesan L. Kamatchi 2928-P os B oard B358 NOREPINEPHRINE UPREGULATES T-TYPE CALCIUM CHANNELS IN RAT PINEALOCYTES. Haijie Yu , Jong Bae Seo, Seung-Ryoung Jung, Duk-Su Koh, Bertil Hille 2929-P os B oard B359 SINGLE-CHANNEL ANALYSIS OF THE INHIBITION OF THE CALCIUM DEPENDENT INACTIVATION BY THE C-TERMINAL MODULATOR DOMAIN OF CAV1.3 CHANNELS. Elza Kuzmenkina , Elena Novikova, Wanchana Jangsangthong, Stefan Herzig 2930-P os B oard B360 SERUM FACTOR ALTERS T-TYPE CAV3.2 GATING KINETICS AND CURRENT DENSITY. Gray Evans , Slobodan M. Todorovic 2931-P os B oard B361 CONVERGENT MODULATIONS BY CARBOXYL-TERMINI ACROSS L-TYPE CALCIUM CHANNEL SUBTYPES. Yaxiong Yang , Min Liu, Nan Liu, Xiaodong Liu 2932-P os B oard B362 MODAL BIFURCATION OF CAV1.3 SIGNALING IN CORTICAL NEURONS. Min Liu , Yaxiong Yang, Nan Liu, Ji Tang, Xuyang Sun, Xiaodong Liu 2933-P os B oard B363 THE EFFECT OF AUTISM CANDIDATE-GENE MUTATIONS IN THE VOLTAGE-GATED CALCIUM CHANNEL β 2 SUBUNIT ON SINGLE CHANNEL KINETICS. Alexandra F. Breitenkamp , Ajay K. Singh, Vincent Mortier, Patrick Despang, Marion Brill, Elza Kuzmenkina, Stefan Herzig 2934-P os B oard B364 DIVERGENT REGULATION OF CARDIOMYOCYTE CAV1.2 CURRENTS BY CALMODULIN MUTANTS ASSOCIATED WITH HUMAN SUDDEN DEATH SYNDROMES. Dmytro O. Kryshtal , Hyun S. Hwang, Christopher N. Johnson, Walter J. Chazin, Alfred L. George Jr., Bjorn C. Knollmann

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland