Biophysical Society 59th Annual Meeting Program Guide

295-P os B oard B75 cpow mid - career travel awardee PROBING THE DOMAIN MOTIONS OF AN OLIGOMERIC PROTEIN FROM DEEP-SEA HYPERTHERMOPHILE BY NEUTRON SPIN ECHO. Debsindhu Bhowmik, Gurpreet Kaur Dhindsa, Andrew J. Rusek, Kurt Van Delinder, Utsab Shrestha, Joseph D. Ng, Melissa Sharp, Laura R. Stingaciu, Xiang-qiang Chu 296-P os B oard B76 THE MECHANISM OF POPULATION SHIFTING AMONG TRANSITION STATES OF ADENYLATE KINASE. Yujing Wang , Emre Onuk, Lee Makowski 297-P os B oard B77 cpow travel awardee MOLECULAR MECHANISM OF RUTHENIUM AND GOLD ANTICANCER AGENTS IN THE ALLOSTERIC REGULATION OF THE HISTONE PROTEINS OF CHROMATIN. Giulia Palermo , Tina Riedel, Curt Alexander Davey, Paul Joseph Dyson, Ursula Rothlisberger 298-P os B oard B78 CHARACTERIZING NUCLEOTIDE DEPENDENT ALLOSTERY IN G-PROTEINS WITH MOLECULAR DYNAMICS AND NORMAL MODE ANALYSIS. Xin-Qiu Yao , Lars Skjærven, Barry J. Grant 299-P os B oard B79 THE EFFECT OF CRYSTAL CONTACT FORCES ON PROTEIN INTRAMOLECULAR DYNAMICS. Andrea Markelz , Katherine Niessen, Mengyang Xu 300-P os B oard B80 THERMODYNAMIC AND DYNAMIC BASIS FOR THE BROADENED LIGAND SPECIFICITY OF A TIAM2 PDZ DOMAIN MUTANT. Ernesto J. Fuentes , Xu Liu, Lisa C. Golden, Liping Yu 301-P os B oard B81 RELATIVE MECHANICAL FLEXIBILITY OF UBIQUITIN FAMILY PROTEINS: A STUDY USING ELASTIC NETWORK MODEL. Ranja Sarkar , Hemachandra Kotamarthi, A.S.R Koti, Ravi Venkatramani 302-P os B oard B82 MOTION AND CONFORMATIONAL ENTROPY IN PROTEIN FUNCTION: CREATION OF AN NMR-BASED ENTROPY METER. Vignesh Kasinath, Kyle W. Harpole, Veronica R. Moorman, Kathleen G. Valentine, Kendra K. Frederick, Kim A. Sharp, Joshua Wand 303-P os B oard B83 A TOOL SET TO MAP DYNAMIC ALLOSTERIC NETWORKS THROUGH THE NMR CHEMICAL SHIFT COVARIANCE ANALYSIS (CHESCA). Stephen Boulton, Madoka Akimoto, Rajeevan Selvaratnam, Amir Bashiri, Giuseppe Melacini 304-P os B oard B84 education travel awardee PROBING MULTIPLE TIMESCALE DYNAMICS OF PROTEIN KINASE A-INHIBITOR COMPLEXES. Geoffrey Li , Jonggul Kim, Frank Chao, Leanna McDonald, Gianluigi Veglia 305-P os B oard B85 LONG-RANGE PROTEIN VIBRATIONS DEPENDENCE ON

307-P os B oard B87 ROLE OF STRUCTURAL FLEXIBILITY OF CPSRP43 IN BINDING SUBSTRATES DURING POST-TRANSLATIONAL TARGETING. Feng Gao, Alicia D. Kight, Rory C. Henderson, Srinivas Jayanthi, Parth Patel, Robyn L. Goforth, T.K.S. Kumar, Ralph L. Henry, Colin D. Heyes 308-P os B oard B88 FLUCTUATIONS WITHIN THE HYDROGEN BOND NETWORK MODULATE COOPERATIVITY ACROSS THE CONFORMATIONAL ENSEMBLE OF PROTEIN STRUCTURES. Brittany K. Smith , Donald J. Jacobs, Dennis R. Livesay Intrinsically Disordered Proteins (IDP) and Aggregates I (Boards B89-B115) 309-P os B oard B89 ANOMALOUS STIFFNESS CHANGES OF TAU PROTEIN IN X-RAY SINGLE MOLECULE OBSERVATIONS. Masahiro Shimura , Yuufuku Matsushita, Keigo Ikezaki, Kouhei Ichiyanagi, Tomohiro Miyasaka, Sekiguchi Hiroshi, Yasuo Ihara, Yuji C. Sasaki 310-P os B oard B90 SIMULATION OF THE DISTRIBUTION OF DISORDERED TAU PROTEINS AROUND ITS AMYLOID FIBRILS CORE. Liang Xu, Martin Margittai, Ruth Nussinov, Buyong Ma 311-P os B oard B91 minority affairs travel awardee TAU FILAMENT LENGTH DISTRIBUTION REFLECTS END-TO- END ANNEALING. Carol J. Huseby , Ralf Bundschuh, Jeff Kuret 312-P os B oard B92 PARAMETER DISTRIBUTION ANALYSIS OF TAU FRAGMENT K18 FIBRILLIZATION. Eri Nakatani-Webster , Shaylin L. Higgins, Abhinav Nath 313-P os B oard B93 HOW UNFOLDED IS TAU? Arash Foroutan , Anne Skaja Robinson 314-P os B oard B94 DISEASE RELATED POINT MUTATIONS AND SOLUTION CONDITIONS DETERMINE FIBRILLIZATION BEHAVIOR OF α -SYNUCLEIN. Arshdeep Sidhu , Ine Segers Nolten, Vinod Subramaniam 315-P os B oard B95 FIBRIL BREAKING ACCELERATES α -SYNUCLEIN FIBRILLIZATION. Volodymyr V. Shvadchak , Mireille M.A.E. Claessens, Vinod Subramaniam 316-P os B oard B96 EXPLORING THE PHASE SPACE OF Α LPHA-SYNUCLEIN WITH REPLICA EXCHANGE SIMULATIONS. Marcin A. Nowosielski , Peter G. Bolhuis 317-P os B oard B97 SINGLE MOLECULE FLUORESCENCE ASSAY OF ALPHA SYNUCLEIN DIMERIZATION. Zhengjian Lv , Alexey V. Krasnoslobodtsev, Yuliang Zhang, Daniel Ysselstein, Jean-Christophe Rochet, Scott Blanchard, Yuri L. Lyubchenko 318-P os B oard B98 ALPHA SYNUCLEIN’S ANOMALOUS STRUCTURAL FLUCTUATIONS IN X-RAY SINGLE MOLECULE OBSERVATIONS. Naruki Hara , Masahiro Shimura, Yufuku Matsushita, Keigo Ikezaki, Hiroshi Sekiguchi, Yasushi Kawata, Yuji C. Sasaki

LIGAND BINDING: RATE PROMOTING MOTIONS. Katherine A. Niessen , Edward Snell, Andrea G. Markelz 306-P os B oard B86

RHODOPSIN PHOTOACTIVATION DYNAMICS REVEALED BY QUASI-ELASTIC NEUTRON SCATTERING. Debsindhu Bhowmik , Utsab Shrestha, Suchithranga M. d. c. Perera, Udeep Chawla, Eugene Mamontov, Michael F. Brown, Xiang-Qiang Chu

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland