Biophysical Society 59th Annual Meeting Program Guide

598-P os B oard B378 THE CONFORMATION OF KCSA’S SELECTIVITY FILTER INFLUENCES THE OPENING OF ITS ACTIVATION GATE. Cholpon Tilegenova , D. Marien Cortes, Luis G. Cuello 599-P os B oard B379 ENGINEERING HERG CHANNEL INNER CAVITY WITHIN KCSA STRUCTURE. Luis G. Cuello , D. Marien Cortes 600-P os B oard B380 PIP2 MODIFIES THE FREE ENERGY OF THE KV1.2 VOLTAGE- SENSOR ACTIVATION. Marina A. Kasimova , Lucie Delemotte, Michael L. Klein, Vincenzo Carnevale, Mounir Tarek 601-P os B oard B381 K + -DEPENDENT SELECTIVITY AND EXTERNAL CALCIUM BLOCK OF SHAB POTASSIUM CHANNELS. Froylan Gomez-Lagunas , Elisa Carrillo 602-P os B oard B382 TIME-DEPENDENT VOLTAGE SENSOR RELAXATION IN HERG CHANNELS. Samrat Thouta , Yu Patrick Shi, Stanislav Sokolov, Yen May Cheng, Tom W.Claydon 603-P os B oard B383 BLOCK OF HERG BY EXTRACELLULAR CALCIUM AND OTHER DIVALENT IONS. Andrew Nguyen, Alice Wong, Angad Oberoi, Thuyvy Le, Alan Miller 604-P os B oard B384 EXTERNAL PROTONS DESTABILIZE THE RELAXED STATE OF THE HERG CHANNEL VOLTAGE SENSOR. Yu Patrick Shi , Samrat Thouta, Yen May Cheng, Tom W. Claydon 605-P os B oard B385 NOVEL VOLTAGE PROTOCOLS FOR DETERMINING HERG CHANNEL KINETICS. Gary R. Mirams , Kylie Beattie, James B. Louttit, Teun de Boer, David J. Gavaghan 606-P os B oard B386 STOICHIOMETRY OF A HERG1 AGONIST ON CHANNEL GATING. Wei Wu , Alison Gardner, Frank Sachse, Michael Sanguinetti 607-P os B oard B387 MOLECULAR ORIGINS OF STATE-DEPENDENT HERG1 BLOCKADE BY DOFETILIDE. Yibo Wang , Laura Perissinotti, Jiqing Guo, Henry J. Duff, Sergei Yu. Noskov 608-P os B oard B388 THE ROLE OF MET-691 IN HEME-DEPENDENT REGULATION SUPPORTS THE PRESENCE OF A CYTOCHROME-C-LIKE STRUCTURE IN HUMAN BK CHANNELS. Taleh Yusifov , Nicoletta Savalli, Saemi Park, Antonios Pantazis, Riccardo Olcese 609-P os B oard B389 THE HEME-BOUND HUMAN BK CHANNEL GATING RING IS A CO SENSOR. Taleh Yusifov , Nicoletta Savalli, Stefan H. Heinemann, Toshinori Hoshi, Riccardo Olcese 610-P os B oard B390 A NOVEL APPROACH FOR LOCATING THE SITES OF DRUG ACTION ON BK CHANNELS. Yanyan Geng , Alice Butler, Lawrence B. Salkoff, Karl M. Magleby 611-P os B oard B391 CADMIUM COORDINATION BY CYSTEINES INTRODUCED IN THE BK INNER PORE AND ITS STRUCTURAL AND FUNCTIONAL IMPLICATIONS. Yu Zhou , Xiaoming Xia, Christopher J. Lingle

585-P os B oard B365 STATE DEPENDENT PHOTO-CROSSLINKING OF THE IKS CHANNEL COMPLEX DEMONSTRATES MOVEMENT OF KCNE1 AT PRE-OPENING MEMBRANE POTENTIALS. Christopher I. Murray , Maartje Westhoff, Yasmeen Maurice, Jodene Eldstrom, David Fedida 586-P os B oard B366 TESTING THE HYDRATION STATUS OF THE SHAKER-K CHANNEL VOLTAGE SENSOR DOMAIN WITH SUGARS. Ignacio Díaz-Franulic , David Naranjo 587-P os B oard B367 THE EFFECT OF D2O ON THE INACTIVATION KINETICS AND RECOVERY FROM SLOW INACTIVATION OF SHAKER-IR K + CHANNELS. Tibor G. Szanto, Orsolya Szilagyi, Gyorgy Panyi 588-P os B oard B368 NON-CANONICAL START CODONS REINITIATE TRANSLATION IN N-TERMINAL TRUNCATED KV CHANNELS. Tanja Kalstrup , Rikard Blunck 589-P os B oard B369 ACTIVATION GATE REGION INFLUENCES STOICHIOMETRY OF HETEROMERIC SHAKER FAMILY CHANNELS. Aditya Pisupati , William J. Horton, Keith Mickolajczyk, Xiaofan Li, Jose Chu, William O. Hancock, Timothy Jegla 590-P os B oard B370 ION PERMEATION IN POTASSIUM CHANNELS INVOLVES DIRECT COULOMB KNOCK-ON BETWEEN IONS. Ulrich Zachariae , David A. Kopfer, Chen Song, Tim Gruene, George M. Sheldrick, Bert L. de Groot 591-P os B oard B371 DYNAMICS OF THE KCSA SELECTIVITY FILTER PROBED USING INTRINSIC TYROSINE FLUORESCENCE. H Raghuraman , Eduardo Perozo 592-P os B oard B372 ROLE OF THE S6-PXP MOTIF IN U-TYPE INACTIVATION OF HETEROTETRAMERIC KV2.1/KV6.4 CHANNELS. Jeroen I. Stas , Elke Bocksteins, Alain J. Labro, Dirk J. Snyders 593-P os B oard B373 VOLTAGE DEPENDENCE OF BK CHANNELS GATING RING MOTION STUDIED BY STATE DEPENDENT FRET. Pablo Miranda , Teresa Giraldez, Miguel Holmgren 594-P os B oard B374 QUANTITATIVE MAPPING OF INTERACTIONS IN THE VOLTAGE-SENSOR PORE INTERFACE OF THE SHAKER POTASSIUM CHANNEL. Kevin Oelstrom , Ana Fernandez-Mariño, Baron Chanda 595-P os B oard B375 BINDING OF QUATERNARY AMMONIUM IONS TO A POTASSIUM CHANNEL. Dylan O. Burdette , Adrian Gross 596-P os B oard B376 STRUCTURE AND DYNAMICS OF THE MTHK K + CHANNEL SELECTIVITY FILTER DURING GATING. David J. Posson , Céline Boiteux, Toby W. Allen, Crina M. Nimigean 597-P os B oard B377 RECONSTITUTION AND MEASUREMENT OF ION CHANNEL ENSEMBLES IN DROPLET BILAYERS. Viksita Vijayvergiya , Shiv Acharya, Jacob Schmidt

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland