Biophysical Society 59th Annual Meeting Program Guide

1018-P lat 4:15 pm UNDERSTANDING SIDE CHAIN CONFORMATIONAL VARIABILITY IN PROTEINS. Asmit Bhowmick , Teresa Head-Gordon 1019-P lat 4:30 pm NAVIGATING IN THE PROTEIN UNIVERSE. Sergey Nepomnyachiy, Rachel Kolodny, Nir Ben-Tal 1020-P lat 4:45 pm PROTEIN EVOLUTION ACROSS FOLD CLASSES: A 3- α -HELIX BUNDLE CAN SWITCH TO β , α / β , AND α + β FOLDS BY STEPWISE MUTATION. Lauren L. Porter , Yanan He, Yihong Chen, John Orban, Philip N. Bryan 1021-P lat 5:00 pm RESOLVING CONFORMATIONAL SWITCHING OF AAA + PROTEASE FTSH USING SINGLE-MOLECULE FRET. Martine Ruer , Philip Gröger, Nadine Bölke, Andreas Hartmann, Michael Schlierf 1022-P lat 5:15 pm ANTI-PRION LIGAND BINDING PROMOTES NATIVE PRP FOLDING OVER MISFOLDING AT THE SINGLE MOLECULE LEVEL. Krishna P. Neupane , Amar Nath Gupta, Negar Rezajooei, Michael T. Woodside 1023-P lat 5:30 pm WHAT COMPUTATIONAL METHODS CAN TEACH US ABOUT THE ALZHEIMER-PROTECTIVE NATURE OF A2V- AND A2T- MUTANT AMYLOID-BETA OLIGOMERS. Jessica Nasica-Labouze , Bogdan Tarus, Phuong Nguyen, Philippe Derreumaux 1024-P lat 5:45 pm NMR STRUCTURE REVEALS NOVEL INTERACTIONS BETWEEN INTRINSICALLY DISORDERED PEP-19 AND CALMODULIN. Xu Wang , John A. Putkey Co-Chairs Mark Williams, Northeastern University Rifka Vlijm, Delft University of Technology, The Netherlands 1025-P lat 4:00 pm OLIGOMERIZATION KINETICS OF ORF1P IS CORRELATED WITH LINE1 RETROTRANSPOSITION. M. Nabuan Naufer , Anthony V. Furano, Mark C. Williams 1026-P lat 4:15 pm NUCLEOSOME ASSEMBLY DYNAMICS INVOLVE SPONTANEOUS FLUCTUATIONS IN THE HANDEDNESS OF TETRASOMES. Rifka Vlijm , Mina Lee, Orkide Ordu, Jan Lipfert, Alexandra Lusser, Nynke Dekker, Cees Dekker 1027-P lat 4:30 pm FACILITATED DISSOCIATION OF PROTEIN FROM A SINGLE DNA BINDING SITE. Ramsey I. Kamar , John F. Marko 1028-P lat 4:45 pm international travel awardee PROTEIN-DNA BINDING IN THE ABSENCE OF CONSENSUS BINDING MOTIF. Ariel Afek , Joshua L. Schipper, Raluca Gordân, David B. Lukatsky 4:00 pm –6:00 pm , R oom 309/310 Platform Protein-Nucleic Acid Interactions II

4:00 pm –6:00 pm , B allroom IV Platform Protein Lipid Interactions II

Co-Chairs Sandro Keller, University of Kaiserslautern, Germany Sarah McDonald, Johns Hopkins University 1009-P lat 4:00 pm AN UNUSUAL MEMBRANE-PROTEIN TOPOLOGY FOR SENSING BILAYER THICKNESS AND TRIGGERING BACTERIAL BIOFILM FORMATION. Sandro Keller , Jana Broecker, Sebastian Fiedler, Katharina Gimpl, Martin Textor 1010-P lat 4:15 pm INSIGHTS INTO THE SPECIFICITY OF NEISSERIAL OPA PROTEIN INTERACTIONS WITH HUMAN RECEPTORS. Jennifer N. Martin , Ryan H. Lo, Alison K. Criss, Linda Columbus 1011-P lat 4:30 pm AROMATIC RESIDUES DISPLAY AN ENERGETIC DEPTH- DEPENDENCE IN LIPID BILAYERS THAT CAN BE MODULATED BY NEAREST-NEIGHBOR INTERACTIONS. Sarah K. McDonald 1012-P lat 4:45 pm PROTEIN AND ENVIRONMENTAL DETERMINANTS OF OMP FATE IN LIPOSOMES. Mark Culver , Stephanos Gozali, Alison H. Dewald 1013-P lat 5:00 pm STRUCTURE AND FUNCTION OF THE β -BARREL ASSEMBLY MACHINE AND ITS ASSOCIATED CHAPERONES. Marcelo C. Sousa 1014-P lat 5:15 pm UNFOLDING THE LUMINAL DOMAIN OF BTUB IN A NATIVE BILAYER. Curtis Balusek , James C. Gumbart 1015-P lat 5:30 pm A SUBSET OF ANNULAR LIPIDS IS LINKED TO THE FLIPPASE ACTIVITY OF AN ABC TRANSPORTER. Cherine Bechara , Anne Noll, Nina Morgner, Matteo T. Degiacomi, Robert Tampe, Carol V. Robinson 1016-P lat 5:45 pm “SNORKELING” OF THE CHARGED SIDECHAIN OF A TRANSMEMBRANE PEPTIDE AS DIRECTLY OBSERVED BY DOUBLE ELECTRON-ELECTRON RESONANCE EXPERIMENT. Matthew Donohue, Maxim Voynov, Sergey Milikisiyants, Alex I. Smirnov, Tatyana I. Smirnova

4:00 pm –6:00 pm , R oom 307/308 Platform Protein Structure and Conformation II

Co-Chairs Lauren Porter, University of Maryland Krishna Neupane, University of Alberta, Canada 1017-P lat 4:00 pm

SOLUTION CONFORMATION OF THE UNBOUND HIV-1 PROTEASE DERIVED FROM RESIDUAL DIPOLAR COUPLINGS MEASURED AT AMBIENT AND HIGH-PRESSURE CONDITIONS. Julien Roche , John M. Louis, Ad Bax

72

Biophysical Society 59 th Annual Meeting, Baltimore, Maryland