Biophysical Society 59th Annual Meeting Program Guide

1318-P os B oard B269 INTRACELLULAR SIGNALING PATHWAY OF CARDIAC APOPTOSIS IN THE PREDIABETIC HEART. Leandro Sommese, Marilen Federico, Carolina Zanuzzi, Enrique L. Portiansky, John Dedman, Marcia Kaetzel, Wehrens H. Xander, Alicia Mattiazzi, Julieta Palomeque Intracellular Calcium Channels and Calcium Sparks and Waves I (Boards B270-B288) 1319-P os B oard B270 DYSSYNCHRONOUS HEART FAILURE IS ASSOCIATED WITH SPATIALLY HETEROGENEOUS SPARK DENSITY IN LEFT VENTRICULAR CARDIOMYOCYTES. Justin G. Lichter , Hui Li, Robin Moss, Thomas S. Seidel, John H. Bridge, Frank B. Sachse 1320-P os B oard B271 INFLUENCE OF RYR2 INHIBITION KINETICS ON CALCIUM SPARKS AND WAVES IN A 3D MODEL OF A CARDIAC CELL. Derek R. Laver , Mohammad S. Imtiaz 1321-P os B oard B272 EFFECTS OF TRIAD GEOMETRY AND RYR GATING SCHEME ON SIMULATED SKELETAL MUSCLE SPARKS. János Vincze , Beatrix Dienes, Péter Szentesi, László Csernoch, Derek R. Laver 1322-P os B oard B273 SUBCELLULAR CA CHANNEL DISTRIBUTION AND CA ALTERNANS IN ATRIAL MYOCYTES. Zhen Song , Korogyi Adam, Peter H. Backx, Zhilin Qu 1323-P os B oard B274 COMPLEX EARLY AND DELAYED AFTERDEPOLARIZATION DYNAMICS CAUSED BY VOLTAGE-CALCIUM COUPLING IN CARDIAC MYOCYTES. Zhen Song , Christopher Y. Ko, Michael Nivala, James N. Weiss, Zhilin Qu 1324-P os B oard B275 STRUCTURAL AND FUNCTIONAL DEFECTS OF T-TUBULAR SYSTEM AND THEIR IMPLICATIONS IN CALCIUM RELEASE AND CONTRACTION IN A MOUSE MODEL OF HYPERTROPHIC CARDIOMYOPATHY. Claudia Crocini , Cecilia Ferrantini, Raffaele Coppini, Marina Scardigli, Erica Lazzeri, Claudio Chicchi, Ping Yan, Leslie M. Loew, Jill Tardif, Chiara Tesi, Francesco Vanzi, Elisabetta Cerbai, Francesco S. Pavone, Leonardo Sacconi 1325-P os B oard B276 SIMULTANEOUS DETECTION AND COLOCALIZATION OF CALCIUM SPARKS AND RYANODINE RECEPTOR CLUSTERS IN CARDIAC MYOCYTES. Alex Vallmitjana, Florian Hiess, S.R. Wayne Chen, Leif Hove-Madsen, Raul Benitez 1326-P os B oard B277 REDUCED CA FLUX VIA RYANODINE RECEPTOR CLUSTER SIZE OR UNITARY CURRENT CAN BOTH PROMOTE LONG- LASTING CA SPARKS. Daisuke Sato , Thomas R. Shannon, Donald M. Bers 1327-P os B oard B278 EXPRESSION AND FUNCTION OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS IN THE HEART. Martha Iveth Garcia , Darren Boehning 1328-P os B oard B279 OPPOSITE CHANGES OF CA 2+ WAVE THRESHOLD AND FRACTIONAL SR CA 2+ RELEASE DURING SERCA STIMULATION IN CARDIOMYOCYTES. Miguel Fernandez-Tenorio , Ernst Niggli

1329-P os B oard B280 ELEVATED HOMOCYSTEINE LEVELS RESULT IN CARBONYL FORMATION ON RYR2 AND ENHANCED SENSITIVITY OF SARCOPLASMIC RETICULUM TO ACTIVATION BY CALCIUM. Laura J. Owen , Robert M. Strongin, Jeffrey D. Singer, Jonathan J. Abramson 1330-P os B oard B281 PHOSPHODIESTERASE INHIBITION LEADS TO ACTIVATION OF EPAC AND STIMULATION OF CA 2+ RELEASE FROM BOTH THE GOLGI APPARATUS AND THE SR. Hannah M. Kirton, Zhaokang Yang, Derek S. Steele 1331-P os B oard B282 CARDIAC ALTERNANS OCCURS THROUGH THE SYNERGY OF VOLTAGE- AND CALCIUM-DEPENDENT MECHANISMS. Minh Tuan Hoang-Trong, W Jonathan Lederer, M Saleet Jafri 1332-P os B oard B283 DEVELOPMENT OF CA ALTERNANS IN ATRIAL MYOCYTES IS MODULATED BY ACTION POTENTIAL MORPHOLOGY. Giedrius Kanaporis , Lothar A. Blatter 1333-P os B oard B284 UROCORTIN 2 REGULATES SARCOPLASMIC RETICULUM CALCIUM VIA PHOSPHORYLATION OF PHOSPHOLAMBAN AND SERCA ACTIVATION AND PROTECTS AGAINST PRO- ARRHYTHMIC ALTERNANS IN CARDIAC MYOCYTES FROM NORMAL AND FAILING HEARTS. Stefanie Walther , Joshua N. Edwards, Joshua T. Maxwell, Florentina Pluteanu, Susanne Renz, Burkert Pieske, Lothar A. Blatter 1334-P os B oard B285 CALCIUM MEDIATED MECHANISM OF EARLY AFTERDEPOLARIZATIONS IN LQT2 VENTRICULAR MYOCYTES. Colin M. Rees , Dmitry Terentyev, Bum-Rak Choi, Gideon Koren, Alain Karma 1335-P os B oard B286 MULTISCALE CONSEQUENCES OF SPONTANEOUS CALCIUM RELEASE ON CARDIAC DELAYED AFTERDEPOLARIZATIONS. Christopher Y. Ko , Zhen Song, Zhilin Qu, James N. Weiss 1336-P os B oard B287 FRET-BASED RYR-SELECTIVE DETECTION REVEALS NO SIGNIFICANT COMPETITION BETWEEN CAM AND S100A1 BINDING TO RYRS. Robyn T. Rebbeck , Florentin R. Nitu, David Rohde, Patrick Most, Donald M. Bers, David D. Thomas, Razvan L. Cornea 1337-P os B oard B288 CALMODULIN POTENTIATES RYR2 BLOCK AND CA WAVE SUPPRESSION BY FLECAINIDE. Nieves Gomez-Hurtado, Ye W. Oo, Derek Laver, Bjorn C. Knollmann Excitation-Contraction Coupling I (Boards B289-B316) 1338-P os B oard B289 international travel awardee DOXORUBICIN ALTERS CARDIOMYOCYTE CALCIUM REGULATION AND STIMULATES MITOCHONDRIAL SUPEROXIDE FLASH PRODUCTION. Nicole Beard , Amy Hanna, Lan Wei-LaPierre, Kevin Tylock, Hermia Willemse, Angela Dulhunty, Robert Dirksen

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland