Biophysical Society 59th Annual Meeting Program Guide

1456-P os B oard B407 STUDYING THE INFLUENCE OF THE SUBUNIT ARRANGEMENT ON THE FUNCTION OF HETEROTETRAMERIC OLFACTORY CNG CHANNELS. Jana Schirmeyer , Vasilica Nache, Gunter Ehrlich, Thomas Zimmer, Klaus Benndorf 1457-P os B oard B408 EFFECT OF LIGAND BINDING TO THE B1B SUBUNIT OF OLFACTORY CNG CHANNELS. Vasilica Nache , Nisa Wongsamitkul, Thomas Zimmer, Klaus Benndorf 1458-P os B oard B409 education travel awardee EXPLORATIONS OF LIPID EFFECTS IN CYCLIC NUCLEOTIDE-GATED ION CHANNELS USING A NANODISC PLATFORM. Alexis Jaramillo Cartagena , Crina Nimigean, Julia Kowal, Henning Stahlberg Cardiac Muscle Mechanics and Structure I (Boards B410-B430) 1459-P os B oard B410 SELECTIVE ALPHA7 NICOTINIC RECEPTOR AGONIST INCREASES CARDIAC FUNCTION IN ISOLATED MOUSE HEARTS BY A NON-NICOTINIC MECHANISM. Cyrus G. Takahashi , Pooja Jagadish, Ashwin Jagadish, John P. Toscano, Nazareno Paolocci, Donald B. Hoover 1460-P os B oard B411 LIFE-LONG TREATMENT WITH LATE SODIUM CURRENT BLOCKER REDUCES MYOCARDIAL DYSFUNCTION AND REMODELING IN A MOUSE MODEL OF HYPERTROPHIC CARDIOMYOPATHY. Francesca Gentile , Raffaele Coppini, Cecilia Ferrantini, Luca Mazzoni, Manuel J Pioner, Benedetta Tosi, Beatrice Scellini, Alessandro Mugelli, Elisabetta Cerbai, Jill Tardif, Chiara Tesi, Corrado Poggesi 1461-P os B oard B412 STAGE-DEPENDENT BENEFITS AND RISKS OF PIMOBENDAN IN GENETIC DILATED CARDIOMYOPATHY MICE WITH PROGRESSIVE HEART FAILURE. Miki Nonaka , Takashi Murayama, Nagomi Kurebyashi, Lei Li, Yuan-Yuan Wang, Sachio Morimoto 1462-P os B oard B413 SAXAGLIPTIN PRESERVES CARDIOMYOCYTE FUNCTION AND MORPHOLOGY IN AORTIC-BANDED MINI-SWINE. Jessica A. Hiemstra , Dong I. Lee, Ann K. Gibson, Melissa S. Cobb, Craig A. Emter, Timothy L. Domeier 1463-P os B oard B414 DIRECT CARDIOTONIC ACTION OF QUERCETIN, A PLANT FLAVONOID, THROUGH MECHANISM INDEPENDENT OF ITS ANTI-OXIDATIVE ACTION. Kengo Hayamizu , Miki Nonaka, Toshihiro Noma, Toshiyuki Sasaguri, Sachio Morimoto 1464-P os B oard B415 DCM MUTATION ACTC E361G CAUSES UNCOUPLING OF MYOFIBRIL SENSITIVITY FROM TNI PHOSPHORYLATION THAT CAN BE REVERSED BY EPIGALLOCATECHIN-3- GALLATE. Petr G. Vikhorev , Weihua Song, Ross Wilkinson, O’Neal Copeland, Michael A. Ferenczi, Steven B. Marston 1465-P os B oard B416 OBSCURIN MUTATIONS CAUSE HAPLOINSUFFICIENCY AND ARE COMMON IN PATIENTS WITH FAMILIAL DILATED CARDIOMYOPATHY (FDCM). Steven Marston , Ralph Knoll, Cristobal dos Remedios, Alex Munster, O’neal Copeland, Cecile Montgiraud

1466-P os B oard B417 DIFFERENTIAL INVOLVEMENT OF VARIOUS SOURCES OF REACTIVE OXYGEN SPECIES IN THYROXIN-INDUCED HEMODYNAMIC CHANGES AND CONTRACTILE DYSFUNCTION OF THE HEART AND DIAPHRAGM MUSCLES. Mohammad T. Elnakish , Eric J. Schultz, Rachel L. Gearinger, Nancy S. Saad, Neha Rastogi, Amany A. E. Ahmed, Peter J. Mohler, Paul M.L. Janssen 1467-P os B oard B418 MECHANICAL EFFECTS OF LATE NA-CURRENT BLOCKERS IN HUMAN HYPERTROPHIC CARDIOMYOPATHY MYOCARDIUM. Cecilia Ferrantini , Raffaele Coppini, Manuel J. Pioner, Gentile Francesca, Tosi Benedetta, Luca Mazzoni, Luiz Belardinelli, Chiara Tesi, Elisabetta Cerbai, Alessandro Mugelli, Corrado Poggesi 1468-P os B oard B419 MYOCARDIAL DYSFUNCTION IN HYPERTROPHIC CARDIOMYOPATHY: PRIMARY EFFECTS OF SARCOMERIC MUTATIONS VERSUS SECONDARY EC-COUPLING REMODELLING. Raffaele Coppini , Cecilia Ferrantini, Francesca Gentile, Luca Mazzoni, Benedetta Tosi, Manuel J. Pioner, Beatrice Scellini, Nicoletta Piroddi, Jil C. Tardiff, Chiara Tesi, Elisabetta Cerbai, Corrado Poggesi 1469-P os B oard B420 R21C MUTATION IN CARDIAC TROPONIN I IMPOSES DIFFERENCES IN THE DEGREE OF ORDER AND KINETICS OF MYOSIN CROSS-BRIDGES OF LEFT AND RIGHT VENTRICLES. Divya Duggal , Janhavi Nagwekar, Ryan Rich, Sangram Raut, Rafal Fudala, Hriday Das, Zygmunt Gryczynski, Ignacy Gryczynski, Julian Borejdo 1470-P os B oard B421 SPATIAL DISTRIBUTION OF ACTIN AND MECHANICAL CYCLE OF MYOSIN ARE DIFFERENT IN RIGHT AND LEFT VENTRICLES OF HEALTHY MOUSE HEARTS. Janhavi Nagwekar , Divya Duggal, Ryan Rich, Sangram Raut, Rafal Fudala, Ignacy Gryczynski, Zygmunt Gryczynski, Julian Borejdo 1471-P os B oard B422 UPREGULATION OF α 1A-SUBTYPE ADRENERGIC SIGNALING IS BENEFICIAL IN FAILING RIGHT VENTRICLE (RV). Patrick M. Cowley , Guanying Wang, Audrey N. Chang, David H. Lovett, James T. Stull, Paul C. Simpson, Anthony J. Baker 1472-P os B oard B423 WORKLOOP CONTRACTIONS IN ISOLATED CARDIAC MYOCYTES REFLECT IN VIVO PRESSURE-VOLUME DYSFUNCTION IN RAT RIGHT HEART FAILURE. Ewan D. Fowler , Mark J. Drinkhill, Rob C. Wust, Michiel Helmes, Ger J.M. Stienen, Derek S. Steele, Ed White 1473-P os B oard B424 USING OPTICAL COHERENCE TOMOGRAPHY TO MEASURE DYNAMIC CHANGES IN THE GEOMETRY OF ISOLATED CARDIAC TRABECULAE DURING A TWITCH. Ming L. Cheuk , Alexander J. Anderson, June-Chiew Han, Bryan P. Ruddy, Marie-Louise Ward, Denis S. Loiselle, Poul M. F. Nielsen, Andrew J. Taberner 1474-P os B oard B425 SYNCHRONIZATION MODEL OF SARCOMERES IN CONTRACTING CARDIOMYOCYTES. Virginijus Barzda , Nicole Prent, Masood Samim, Sara Wegener, Richard Cisek

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland