Biophysical Society 59th Annual Meeting Program Guide

1499-P os B oard B450 ALTERED STRUCTURAL STATE OF ACTIN FILAMENTS UPON MYOSIN II BINDING. Elina Bengtsson , Malin Persson, Saroj Kumar, Alf Månsson 1500-P os B oard B451 PHOSPHOMIMIC S3D COFILIN BINDS ACTIN FILAMENTS BUT DOES NOT SEVER THEM. W. Austin Elam , Hyeran Kang, Ewa Prochniewicz, Karina Nieves-Torres, David D. Thomas, Enrique M. De La Cruz 1501-P os B oard B452 PALLADIN’S IG4 MUTATION: EXPLORING THE LINK WITH PANCREATIC CANCER. Stan Saiz , Joseph Dille, Rahul Yadav, Moriah Beck 1502-P os B oard B453 DYNAMIC ACTOMYOSIN NETWORK MORPHOLOGY IN 3D MODEL OF CYTOKINETIC RING ASSEMBLY. Tamara C. Bidone , Haosu Tang, Dimitrios Vavylonis 1503-P os B oard B454 HUMAN TUMOR-ASSOCIATED FIBROBLASTS CAN SENSE THE TOPOGRAPHY OF THEIR ENVIRONMENT. Mikheil Azatov , Xiaoyu Sun, John Fourkas, Carol Otey, Arpita Upadhyaya Myosins (Boards B455-B472) 1504-P os B oard B455 MACROMOLECULAR CROWDING INCREASES CROSS-BRIDGE PERFORMANCE VIA REDUCTION OF ADP AFFINITY TO ACTO-MYOSIN. Jinghua Ge, Sherry Bouriyaphon, Yuri E. Nesmelov 1505-P os B oard B456 education travel awardee MACROMOLECULAR CROWDING MODULATES CROSS- BRIDGE PERFORMANCE. Jinghua Ge , Sherry D. Bouriyaphone, Yuri E. Nesmelov 1506-P os B oard B457 MUTATING THE SH1 HELIX REGION OF DICTYOSTELIUM MYOSIN II IMPAIRS MOTILE ACTIVITIES AND THERMAL STABILITY. Kotomi Shibata 1507-P os B oard B458 A MYOSIN II FRET-BASED BIOSENSOR EXPRESSED IN DICTYOSTELIUM. Jared G. Matzke , David D. Thomas, Karl J. Petersen, Joseph M. Muretta, Margaret A. Titus 1508-P os B oard B459 THE INHIBITED, INTERACTING-HEADS MOTIF CHARACTERIZES MYOSIN II FROM THE EARLIEST ANIMALS WITH MUSCLES. Guidenn Sulbarán, Ji Young Mun, Kyoung Hwan Lee, Lorenzo Alamo, Antonio Pinto, Osamu Sato, Mitsuo Ikebe, Xiong Liu, Edward D. Korn, Raúl Padrón, Roger Craig 1509-P os B oard B460 DETECTION OF ULTRAFAST MECHANICAL TRANSITIONS IN Β -CARDIAC MYOSIN USING HIGH-SPEED OPTICAL TRAPPING. Michael S. Woody , Marco Capitanio, E. Michael Ostap, Yale E. Goldman 1510-P os B oard B461 CONVERTER MUTATION DISRUPTS LEVER ARM ROTATION IN MYOSIN V. Anja M. Swenson, Darshan V. Trivedi, Christopher M. Yengo

1511-P os B oard B462 MYOSIN STEPS SYMMETRICALLY ALONG ACTIN. Jaime Ortega Arroyo , Joanna Andrecka, Gabrielle de Wit, Yasuharu Takagi, James R. Sellers, Philipp Kukura 1512-P os B oard B463 MYOSIN-5 AND MYOSIN-6 DIFFERENTIALLY DETECT ACTIN FILAMENT AGE. Dennis Zimmermann, Alicja Janik, David Kovar, Ronald Rock 1513-P os B oard B464 ADAPTER PROTEINS ACTIVATE MYOSIN-VA DURING CARGO TRANSPORT. M. Yusuf Ali , Elena Krementsova, Maria Sckolnick, David M. Warshaw, Kathleen M. Trybus 1514-P os B oard B465 ACTIVATION OF DROSOPHILA MELANOGASTER MYOSIN-5 MOTOR FUNCTION BY CALCIUM AND CARGO-BINDING PROTEIN. Huan-Hong Ji , Hai-Man Zhang, Mei Shen, Xiang-dong Li 1515-P os B oard B466 14-3-3 PROTEINS TUNE NON-MUSCLE MYOSIN-II ASSEMBLY, PROVIDING A POSSIBLE BRIDGE BETWEEN CELL MECHANICS AND CANCER METASTASIS. Hoku West-Foyle , Jonathan Osborne, Douglas Robinson 1516-P os B oard B467 FILOPOD EXTENSION REQUIRES MYTH4-FERM MYOSIN MOTOR ACTIVITY. Karl J. Petersen , G.W. Gant Luxton, Margaret A. Titus 1517-P os B oard B468 MYOSIN 19 IS ANCHORED TO THE MITOCHONDRIA, AFFECTING ITS LOCALIZATION AND MORPHOLOGY. Boris Shneyer , Marko Usaj, Arnon Henn 1518-P os B oard B469 IN VIVO AND IN VITRO STUDIES OF MYOSIN-XXI DYNAMICS. Constanze Helbig , Christopher Batters, Beate Averbeck, Claudia Veigel 1519-P os B oard B470 THE R249Q AND R146N HYPERTROPHIC CARDIOMYOPATHY MYOSIN MUTATIONS DECREASE MUSCLE FORCE AND POWER GENERATION. Kaylyn Bell , William A. Kronert, Sanford I. Bernstein, Douglas M. Swank 1520-P os B oard B471 A DROSOPHILA MODEL OF MYOSIN-BASED INCLUSION BODY MYOPATHY TYPE 3: EFFECTS ON MUSCLE STRUCTURE, MUSCLE FUNCTION AND AGGREGATED PROTEIN PROFILES. Jennifer A. Suggs, Girish C. Melkani, Anju Melkani, Eric P. Ratliff, D Brian Foster, Sanford I. Bernstein 1521-P os B oard B472 FUNCTIONAL ANALYSIS OF FREEMAN-SHELDON SYNDROME CAUSING MUTATIONS ON EMBRYONIC MYOSIN. Carlos Vera Velazquez , Jonathan Walklate, Jonathan Deacon, Michael A. Geeves, Leslie A. Leinwand Cell Mechanics, Mechanosensing, and Motility II (Boards B473-B490) 1522-P os B oard B473 COMPARISON OF STOCHASTIC SIMULATION METHODS IN MECHANOBIOLOGY. Sarita Koride , Sean X. Sun

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland